Cortical and Subcortical Contributions to Short-Term Memory for Orienting Movements.
Cortical and Subcortical Contributions to Short-Term Memory for Orienting Movements.
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DOI：
10.1016/j.neuron.2015.08.033
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发表时间：
2015-10-21
期刊：
影响因子：
16.2
通讯作者：
Brody CD
中科院分区：
文献类型：
--
作者：
Kopec CD;Erlich JC;Brunton BW;Deisseroth K;Brody CD
额叶皮质区的神经活动与短时记忆（STM）有因果关系，但这种活动是否是形成、维持或阅读STM所必需的，目前尚不清楚。在执行记忆引导定向任务的大鼠中，皮层中的额叶定向场（FOF）被认为是STM维持的关键，并且在每次试验期间，显示出对STM的单调增加的神经编码。在这里，我们暂时失活FOF或上级丘，并发现由此产生的记忆引导定向性能的损伤遵循单调递减的时间过程，令人惊讶的是相反的神经编码。一个动态吸引子模型，其中STM同样依赖于皮层和皮层下区域协调的编码和失活数据。我们证实了该模型的关键预测，包括审判难度和扰动性之间的时间依赖性关系，以及在记忆维持期间FOF和上级丘同时失活后的实质性超线性损伤。
Neural activity in frontal cortical areas has been causally linked to short-term memory (STM), but whether this activity is necessary for forming, maintaining, or reading out STM remains unclear. In rats performing a memory-guided orienting task, the frontal orienting fields in cortex (FOF) are considered critical for STM maintenance, and during each trial, display a monotonically increasing neural encoding for STM. Here, we transiently inactivated either the FOF or the superior colliculus, and found that the resulting impairments in memory-guided orienting performance followed a monotonically decreasing timecourse, surprisingly opposite to the neural encoding. A dynamical attractor model in which STM relies equally on cortical and subcortical regions reconciled the encoding and inactivation data. We confirmed key predictions of the model, including a time-dependent relationship between trial difficulty and perturbability, and substantial, supralinear, impairment following simultaneous inactivation of the FOF and superior colliculus during memory maintenance.
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