Non-pathogenic microbiota accelerate age-related CpG Island methylation in colonic mucosa.
Non-pathogenic microbiota accelerate age-related CpG Island methylation in colonic mucosa.
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DOI：
10.1080/15592294.2022.2160568
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发表时间：
2023-12
期刊：
影响因子：
3.7
通讯作者：
Issa, Jean-Pierre J.
中科院分区：
文献类型：
--
作者：
Sun, Ang;Park, Pyoung Hwa;Cole, Lauren;Vaidya, Himani;Maegawa, Shinji;Keith, Kelsey;Calendo, Gennaro;Madzo, Jozef;Jelinek, Jaroslav;Jobin, Christian;Issa, Jean-Pierre J.
DNA methylation is an epigenetic process altered in cancer and ageing. Age-related methylation drift can be used to estimate lifespan and can be influenced by extrinsic factors such as diet. Here, we report that non-pathogenic microbiota accelerate age-related methylation drift in the colon when compared with germ-free mice. DNA methylation analyses showed that microbiota and IL10KO were associated with changes in 5% and 4.1% of CpG sites, while mice with both factors had 18% alterations. Microbiota, IL10KO, and their combination altered 0.4%, 0.4%, and 4% of CpG island methylation, respectively. These are comparable to what is seen in colon cancer. Ageing changes were accelerated in the IL10KO mice with microbiota, and the affected genes were more likely to be altered in colon cancer. Thus, the microbiota affect DNA methylation of the colon in patterns reminiscent of what is observed in ageing and colorectal cancer.
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影响因子：
7
作者：
Maegawa S;Gough SM;Watanabe-Okochi N;Lu Y;Zhang N;Castoro RJ;Estecio MR;Jelinek J;Liang S;Kitamura T;Aplan PD;Issa JP
通讯作者：
Issa JP
影响因子：
50.3
作者：
Figueroa ME;Abdel-Wahab O;Lu C;Ward PS;Patel J;Shih A;Li Y;Bhagwat N;Vasanthakumar A;Fernandez HF;Tallman MS;Sun Z;Wolniak K;Peeters JK;Liu W;Choe SE;Fantin VR;Paietta E;Löwenberg B;Licht JD;Godley LA;Delwel R;Valk PJ;Thompson CB;Levine RL;Melnick A
通讯作者：
Melnick A
影响因子：
28.3
作者：
Ansari, Ihab;Raddatz, Guenter;Bergman, Yehudit
通讯作者：
Bergman, Yehudit
影响因子：
6.4
作者：
Kumar H;Lund R;Laiho A;Lundelin K;Ley RE;Isolauri E;Salminen S
通讯作者：
Salminen S
DOI：
10.1126/science.1224820
发表时间：
2012-10-05
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Arthur JC;Perez-Chanona E;Mühlbauer M;Tomkovich S;Uronis JM;Fan TJ;Campbell BJ;Abujamel T;Dogan B;Rogers AB;Rhodes JM;Stintzi A;Simpson KW;Hansen JJ;Keku TO;Fodor AA;Jobin C
通讯作者：
Jobin C