Pathogenesis of allergic diseases and implications for therapeutic interventions.
Pathogenesis of allergic diseases and implications for therapeutic interventions.
复制标题
DOI：
10.1038/s41392-023-01344-4
复制
发表时间：
2023-03-24
影响因子：
39.3
通讯作者：
Wang, Qi
中科院分区：
文献类型：
--
作者：
Wang, Ji;Zhou, Yumei;Zhang, Honglei;Hu, Linhan;Liu, Juntong;Wang, Lei;Wang, Tianyi;Zhang, Haiyun;Cong, Linpeng;Wang, Qi
过敏性疾病如过敏性鼻炎（AR）、过敏性哮喘（AAS）、特应性皮炎（AD）、食物过敏（FA）和湿疹是由受损的免疫系统引起的全身性疾病。伴随着高复发率，这些疾病的发病率不断上升，正引起越来越多的关注。变态反应性疾病的发病机制复杂，涉及多种因素，包括母胎环境、生活环境、遗传学、表观遗传学以及机体的免疫状态等。变应性疾病的发病机制表现出明显的异质性，表型和内型分别定义了可见的特征和相关的分子机制。随着免疫学、分子生物学和生物技术的迅速发展，许多新的生物药物被设计用于治疗变应性疾病，包括抗免疫球蛋白E（IgE）、抗白细胞介素（IL）-5和抗胸腺基质淋巴细胞生成素（TSLP）/IL-4，以控制症状。对于医生和科学家来说，了解过敏性疾病的影响因素，发病机制和治疗进展变得越来越重要。本综述旨在评估过敏性疾病（包括AR、AAS、AD和FA）的流行病学、发病机制和治疗干预。我们希望帮助医生和科学家系统地了解过敏性疾病。
Allergic diseases such as allergic rhinitis (AR), allergic asthma (AAS), atopic dermatitis (AD), food allergy (FA), and eczema are systemic diseases caused by an impaired immune system. Accompanied by high recurrence rates, the steadily rising incidence rates of these diseases are attracting increasing attention. The pathogenesis of allergic diseases is complex and involves many factors, including maternal-fetal environment, living environment, genetics, epigenetics, and the body’s immune status. The pathogenesis of allergic diseases exhibits a marked heterogeneity, with phenotype and endotype defining visible features and associated molecular mechanisms, respectively. With the rapid development of immunology, molecular biology, and biotechnology, many new biological drugs have been designed for the treatment of allergic diseases, including anti-immunoglobulin E (IgE), anti-interleukin (IL)-5, and anti-thymic stromal lymphopoietin (TSLP)/IL-4, to control symptoms. For doctors and scientists, it is becoming more and more important to understand the influencing factors, pathogenesis, and treatment progress of allergic diseases. This review aimed to assess the epidemiology, pathogenesis, and therapeutic interventions of allergic diseases, including AR, AAS, AD, and FA. We hope to help doctors and scientists understand allergic diseases systematically.
登录
查看更多内容
影响因子：
5.7
作者：
Arathimos R;Suderman M;Sharp GC;Burrows K;Granell R;Tilling K;Gaunt TR;Henderson J;Ring S;Richmond RC;Relton CL
通讯作者：
Relton CL
影响因子：
5.6
作者：
Zhou Z;Liang S;Zhou Z;Liu J;Meng X;Zou F;Yu C;Cai S
通讯作者：
Cai S
大鼠蛋白质组分析显示，早期哮喘反应与糖酵解、钙结合和线粒体活性有关
影响因子：
5.8
作者：
Xu YD;Cui JM;Wang Y;Yin LM;Gao CK;Liu YY;Yang YQ
通讯作者：
Yang YQ
影响因子：
3.7
作者：
Kankaanranta H;Ilmarinen P;Zhang X;Adcock IM;Lahti A;Barnes PJ;Giembycz MA;Lindsay MA;Moilanen E
通讯作者：
Moilanen E
影响因子：
5.8
作者：
Raby BA;Van Steen K;Lasky-Su J;Tantisira K;Kaplan F;Weiss ST
通讯作者：
Weiss ST