Mechanical regulation of epigenetics in vascular biology and pathobiology.
Mechanical regulation of epigenetics in vascular biology and pathobiology.
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DOI：
10.1111/jcmm.12031
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发表时间：
2013-04
影响因子：
5.3
通讯作者：
Chiu JJ
中科院分区：
文献类型：
--
作者：
Chen LJ;Wei SY;Chiu JJ
血管内皮细胞（EC）和平滑肌细胞（VSMCs）不断暴露于血液动力学的力量，包括血流诱导的流体剪切应力和血压的周期性拉伸。这些力量调节血管细胞基因表达和功能，因此，影响健康和疾病中的血管生理学和病理生理学。表观遗传学，包括DNA甲基化，组蛋白修饰/染色质重塑和基于RNA的机制，是指研究基因表达中的遗传变化，而不发生DNA序列的变化。血液动力诱导的表观遗传修饰在调节血管基因表达和功能中的作用最近已被阐明。本文综述了与血管生理学和病理生理学有关的表观遗传学概念。通过对基因表达、细胞增殖、血管生成、迁移和病理生理状态的研究，我们提出了一个概念框架，用于理解机械力诱导的表观遗传修饰如何控制血管基因表达和功能，从而控制血管疾病的发展。这项研究有助于我们了解机械环境如何影响EC和VSMCs的染色质状态以及随后的细胞行为。
Vascular endothelial cells (ECs) and smooth muscle cells (VSMCs) are constantly exposed to haemodynamic forces, including blood flow-induced fluid shear stress and cyclic stretch from blood pressure. These forces modulate vascular cell gene expression and function and, therefore, influence vascular physiology and pathophysiology in health and disease. Epigenetics, including DNA methylation, histone modification/chromatin remodelling and RNA-based machinery, refers to the study of heritable changes in gene expression that occur without changes in the DNA sequence. The role of haemodynamic force-induced epigenetic modifications in the regulation of vascular gene expression and function has recently been elucidated. This review provides an introduction to the epigenetic concepts that relate to vascular physiology and pathophysiology. Through the studies of gene expression, cell proliferation, angiogenesis, migration and pathophysiological states, we present a conceptual framework for understanding how mechanical force-induced epigenetic modifications work to control vascular gene expression and function and, hence, the development of vascular disorders. This research contributes to our knowledge of how the mechanical environment impacts the chromatin state of ECs and VSMCs and the consequent cellular behaviours.
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影响因子：
64.8
作者：
Cordes KR;Sheehy NT;White MP;Berry EC;Morton SU;Muth AN;Lee TH;Miano JM;Ivey KN;Srivastava D
通讯作者：
Srivastava D
影响因子：
64.8
作者：
Chendrimada, TP;Gregory, RI;Shiekhattar, R
通讯作者：
Shiekhattar, R
影响因子：
14.9
作者：
Deplus, R;Brenner, C;Fuks, F
通讯作者：
Fuks, F
影响因子：
64.5
作者：
Goldberg, Aaron D.;Allis, C. David;Bernstein, Emily
通讯作者：
Bernstein, Emily
DOI：
10.1115/1.2834303
发表时间：
1998-02-01
影响因子：
1.7
作者：
Chiu, JJ;Wang, DL;Usami, S
通讯作者：
Usami, S