Profile and prognosis of patients hospitalized for COVID-19 virus infection with and without diabetes - An observational study from South India.
Profile and prognosis of patients hospitalized for COVID-19 virus infection with and without diabetes - An observational study from South India.
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DOI：
10.1016/j.dsx.2021.05.016
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发表时间：
2021-07
期刊：
影响因子：
--
通讯作者：
Ramachandran A
中科院分区：
文献类型：
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作者：
Raghavan A;Nanditha A;Satheesh K;Susairaj P;Vinitha R;Chandrasekaran S;Palaniappan T;Thillai Vallal S;Subair Khan A;Snehalatha C;Ramachandran A
我们研究了因冠状病毒病19（COVID-19）感染住院的患者的概况和结局，伴或不伴2型糖尿病（T2 DM）。在这项观察性研究中，于2020年5月至11月收集了印度泰米尔纳德邦钦奈市4家医院通过逆转录-聚合酶链反应确诊的COVID-19患者的临床详情。共选择845例患者（n = 423例糖尿病患者，n = 422例非糖尿病患者）进行分析。记录临床详情、生化和放射学检查、糖尿病治疗、重症监护、死亡率和其他不良结局。纳入有T2 DM临床病史、糖化血红蛋白（HbA 1c）≥6.5%（48 mmol/mol）和/或随机血糖≥200 mg/dl（11.1 mmol/l）的患者。采用卡方检验或t检验和多元Logistic回归分析进行统计学分析。入院时，T2 DM患者年龄较大（p < 0.0001），合并症如冠状动脉疾病（p = 0.02）、高血压（p < 0.0001）、甲状腺功能减退（p = 0.03）和肾脏疾病（p = 0.01）高于非糖尿病患者。他们对深切治疗的需求较高。急性肾损伤或衰竭、肺炎和心肌梗死在T2 DM中的发生率较高。T2 DM的死亡率显著较高（10.2% vs 5.9%，p = 0.02）。然而，在多元逻辑回归分析中，只有年龄（p < 0.0001）和肾脏疾病（p = 0.002）与死亡率显著相关。我们的研究表明，在因COVID-19感染住院的患者中，死亡率与较高的年龄和肾脏疾病相关，但未显示与糖尿病相关。
We studied the profile and outcome of patients hospitalized for coronavirus disease-19 (COVID-19) infection with and without type 2 diabetes (T2DM). In this observational study, clinical details of patients with COVID-19, identified by Reverse Transcription – Polymerase Chain Reaction admitted to 4 hospitals in Chennai, Tamil Nadu, India were collected from May to November 2020. A total of 845 (n = 423 with diabetes, n = 422 without diabetes) were selected for the analysis. Clinical details, biochemical and radiological investigations, diabetes treatment, intensive care, mortality and other adverse outcomes were recorded. Patients with clinical history of T2DM, glycosylated haemoglobin (HbA1c) of ≥6.5% (48 mmol/mol) and/or random blood glucose ≥200 mg/dl (11.1 mmol/l) were included. Statistical analyses were done using chi-square or ‘t’ test and multiple logistic regression analysis. At admission, patients with T2DM were older (p < 0.0001), had higher co-morbidities such as coronary artery disease (p = 0.02), hypertension (p < 0.0001), hypothyroidism (p = 0.03) and renal disorders (p = 0.01) than non-diabetes persons. Requirement for intensive care was higher among them. Acute renal injury or failure, pneumonia and myocardial infarction developed in higher percentage of T2DM. Mortality was significantly higher in T2DM (10.2% vs 5.9%, p = 0.02). However, in the multiple logistic regression analysis, only age (p < 0.0001) and renal disorders (p = 0.002) were significantly associated with mortality. Our study showed that mortality was associated with higher age and renal disorders but did not show an association with diabetes, among patients hospitalized for COVID-19 infection.
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影响因子：
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作者：
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通讯作者：
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DOI：
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发表时间：
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期刊：
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