Mortality Rate and Predictors of Mortality in Hospitalized COVID-19 Patients with Diabetes.
Mortality Rate and Predictors of Mortality in Hospitalized COVID-19 Patients with Diabetes.
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DOI：
10.3390/healthcare8030338
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发表时间：
2020-09-13
期刊：
影响因子：
--
通讯作者：
Moon SS
中科院分区：
文献类型：
--
作者：
Acharya D;Lee K;Lee DS;Lee YS;Moon SS
研究证实，患有糖尿病的COVID-19患者的死亡风险高于非糖尿病患者。然而，在韩国，与住院的COVID-19糖尿病患者死亡风险增加相关的因素的数据驱动证据很少。本研究旨在确定韩国庆尚北-做省住院的COVID-19 2型糖尿病患者的死亡率并确定死亡风险因素。在这项以医院为基础的横断面研究中，我们共招募了324名确诊COVID-19的患者，他们于2020年2月18日至6月30日期间在韩国庆尚北-做的两所三级医疗机构住院。对人口统计学和临床数据以及实验室资料进行分析，并使用多变量logistic回归分析来确定COVID-19糖尿病患者死亡的风险因素。在324例患者中，55例（16.97%）患有糖尿病。所有研究受试者的平均年龄为55岁，糖尿病患者的平均年龄大于非糖尿病患者（69.8岁vs. 51.9岁）。值得注意的是，糖尿病患者的死亡率要高得多（20.0%对4.8%）。多变量logistic回归分析显示，年龄较大（≥70岁）和血清乳酸脱氢酶（LDH）水平高可显著预测住院COVID-19糖尿病患者的死亡率。我们的研究提醒更多关注因COVID-19住院的糖尿病患者，特别是年龄≥ 70岁和血清LDH水平高的患者，以降低死亡风险。
Studies have confirmed COVID-19 patients with diabetes are at higher risk of mortality than their non-diabetic counterparts. However, data-driven evidence of factors associated with increased mortality risk among hospitalized COVID-19 patients with diabetes is scarce in South Korea. This study was conducted to determine the mortality rate and identify risk factors of mortality among hospitalized COVID-19 patients with type 2 diabetes in Gyeongsangbuk-do province, South Korea. In this hospital-based, cross-sectional study, we enrolled a total of 324 patients with confirmed COVID-19, hospitalized at two of the tertiary level healthcare facilitates of Gyeongsangbuk-do, South Korea from 18 February to 30 June 2020. Demographic and clinical data and laboratory profiles were analyzed and multivariate logistic regression analysis was used to identify risk factors of mortality among diabetic patients with COVID-19. Of the 324 patients, 55 (16.97%) had diabetes mellitus. The mean age of all study subjects was 55 years, and the mean age of those with diabetes was greater than that of those without (69.8 years vs. 51.9 years). Remarkably, the mortality rate was much higher among those with diabetes (20.0% vs. 4.8%). Multivariate logistic regression analysis revealed that an older age (≥70 years) and a high serum lactate dehydrogenase (LDH) levels significantly predicted mortality among hospitalized COVID-19 patients with diabetes. Our study cautions more attention to be paid to patients with diabetes mellitus hospitalized for COVID-19, especially those aged ≥ 70 years and those with a high serum LDH level, to reduce the risk of mortality.
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