Recent updates on the melanin-concentrating hormone (MCH) and its receptor system: lessons from MCH1R antagonists.
Recent updates on the melanin-concentrating hormone (MCH) and its receptor system: lessons from MCH1R antagonists.
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DOI：
10.1007/s12031-010-9411-4
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发表时间：
2011-01
影响因子：
3.1
通讯作者：
Civelli, Olivier
中科院分区：
文献类型：
--
作者：
Chung, Shinjae;Parks, Gregory S.;Lee, Cheol;Civelli, Olivier
关键词：
黑色素浓缩激素（MCH）是一种19个氨基酸的环状肽，最初发现它可以使鱼类的肤色变浅，在许多物种中高度保守。MCH与两种G蛋白偶联受体MCH1R和MCH2R相互作用，但只有MCH1R在啮齿动物中表达。MCH主要在外侧下丘脑和齿状回合成，而MCH 1R在整个大脑中广泛表达。因此，MCH信号转导涉及许多生理功能的调节。MCH1R的鉴定导致了可以阻断MCH信号传导的小分子MCH1R拮抗剂的开发。MCH1R拮抗剂不仅具有潜在的治疗价值，而且有助于了解内源性MCH系统的生理功能。在这里，我们回顾了MCH系统的生理功能，已调查使用MCH1R拮抗剂，如食物摄入，焦虑，抑郁，奖励和睡眠。这将有助于我们了解MCH系统的生理功能，并提出一些潜在的应用MCH1R拮抗剂在人类疾病。
Melanin-concentrating hormone (MCH) is a 19-amino-acid cyclic peptide which was originally found to lighten skin color in fish that is highly conserved among many species. MCH interacts with two G-protein-coupled receptors, MCH1R and MCH2R, but only MCH1R is expressed in rodents. MCH is mainly synthesized in the lateral hypothalamus and zona incerta, while MCH1R is widely expressed throughout the brain. Thus, MCH signaling is implicated in the regulation of many physiological functions. The identification of MCH1R has led to the development of small-molecule MCH1R antagonists that can block MCH signaling. MCH1R antagonists are useful not only for their potential therapeutic value, but also for understanding the physiological functions of the endogenous MCH system. Here, we review the physiological functions of the MCH system which have been investigated using MCH1R antagonists such as food intake, anxiety, depression, reward, and sleep. This will help us understand the physiological functions of the MCH system and suggest some of the potential applications of MCH1R antagonists in human disorders.
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影响因子：
21.3
作者：
Lembo, PMC;Grazzini, E;Walker, P
通讯作者：
Walker, P
影响因子：
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作者：
Erondu, Ngozi;Gantz, Ira;Heymsfield, Steven B.
通讯作者：
Heymsfield, Steven B.
DOI：
10.1124/jpet.104.081711
发表时间：
2005-05-01
影响因子：
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作者：
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通讯作者：
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影响因子：
82.9
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通讯作者：
Palmiter, RD
影响因子：
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作者：
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通讯作者：
Katugampola, Sidath D.