Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives.
Bone regeneration strategies: Engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives.
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DOI：
10.1016/j.biomaterials.2018.07.017
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发表时间：
2018-10
期刊：
影响因子：
14
通讯作者：
Picart C
中科院分区：
文献类型：
--
作者：
Ho-Shui-Ling A;Bolander J;Rustom LE;Johnson AW;Luyten FP;Picart C
骨折是人类最常见的创伤性损伤。骨折的修复是一个再生的过程，重演了胚胎骨骼发育的许多生物学事件。大多数情况下，它会导致成功愈合和受损骨骼的恢复。不幸的是，大约5-10%的骨折会导致延迟愈合或不愈合，在合并症如糖尿病的情况下更是如此。在这篇文章中，我们回顾了不同的策略，以愈合骨缺损，使用合成骨移植替代品和生物活性物质或干细胞。我们的综述与以往的综述不同，以往的综述侧重于仍处于早期开发阶段的策略，并且主要使用细胞系或干细胞的体外实验。在这里，我们重点关注已经在临床上实施的，目前正在临床试验中的，以及已经在动物模型中测试的。治疗方法可以分为三大类：i）合成骨移植替代物（BGS），其结构和表面可以优化; ii）BGS与生物活性分子如生长因子、肽或靶向骨前体细胞、骨形成和代谢的小分子组合; iii）基于细胞的策略，其中祖细胞与活性分子组合或不与活性分子组合，所述活性分子可以注射或接种在BGS上以改善递送。我们回顾了主要类型的成人基质细胞（骨髓，脂肪和骨膜来源），已被使用，并比较它们的性能。最后，我们讨论了剩余的挑战，需要解决显着提高骨缺损的愈合。
Bone fractures are the most common traumatic injuries in humans. The repair of bone fractures is a regenerative process that recapitulates many of the biological events of embryonic skeletal development. Most of the time it leads to successful healing and the recovery of the damaged bone. Unfortunately, about 5-10% of fractures will lead to delayed healing or non-union, more so in the case of co-morbidities such as diabetes. In this article, we review the different strategies to heal bone defects using synthetic bone graft substitutes and biologically active substances or stem cells. Our review is different from previous reviews, which focus on strategies that are still at the early stages of development and use mostly in vitro experiments with cell lines or stem cells. Here, we focus on what is already implemented in the clinics, what is currently in clinical trials, and what has been tested in animal models. Treatment approaches can be classified in three major categories: i) synthetic bone graft substitutes (BGS) whose architecture and surface can be optimized; ii) BGS combined with bioactive molecules such as growth factors, peptides or small molecules targeting bone precursor cells, bone formation and metabolism; iii) cell-based strategies with progenitor cells combined or not with active molecules that can be injected or seeded on BGS for improved delivery. We review the major types of adult stromal cells (bone marrow, adipose and periosteum derived) that have been used and compare their properties. Finally, we discuss the remaining challenges that need to be addressed to significantly improve the healing of bone defects.
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影响因子：
4.6
作者：
Billing AM;Ben Hamidane H;Dib SS;Cotton RJ;Bhagwat AM;Kumar P;Hayat S;Yousri NA;Goswami N;Suhre K;Rafii A;Graumann J
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