Designing stem cell niches for differentiation and self-renewal.
Designing stem cell niches for differentiation and self-renewal.
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设计用于分化和自我更新的干细胞生态位。
DOI：
10.1098/rsif.2018.0388
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发表时间：
2018-08
期刊：
影响因子：
--
通讯作者：
Dalby MJ
中科院分区：
文献类型：
--
作者：
Donnelly H;Salmeron-Sanchez M;Dalby MJ
间充质干细胞具有分化为骨骼组织和自我更新的能力，在再生医学和新的治疗发现方面都有很大的希望。然而，它们的再生能力只有在与它们的特殊微环境（称为干细胞龛）接触时才能保留。小生境提供生物化学和生物物理的结构和功能线索，干细胞将这种复杂的信号阵列与内在调控网络整合以满足生理需求。虽然，其中一些监管机制仍然知之甚少，或难以利用传统文化系统。生物材料的战略正在开发，旨在重演干细胞的利基，工程微环境与生理一样的利基属性，旨在阐明干细胞的调控机制，并利用其再生能力在体外。在未来，工程利基将被证明是再生医学和治疗发现的重要工具。
Mesenchymal stem cells, characterized by their ability to differentiate into skeletal tissues and self-renew, hold great promise for both regenerative medicine and novel therapeutic discovery. However, their regenerative capacity is retained only when in contact with their specialized microenvironment, termed the stem cell niche. Niches provide structural and functional cues that are both biochemical and biophysical, stem cells integrate this complex array of signals with intrinsic regulatory networks to meet physiological demands. Although, some of these regulatory mechanisms remain poorly understood or difficult to harness with traditional culture systems. Biomaterial strategies are being developed that aim to recapitulate stem cell niches, by engineering microenvironments with physiological-like niche properties that aim to elucidate stem cell-regulatory mechanisms, and to harness their regenerative capacity in vitro. In the future, engineered niches will prove important tools for both regenerative medicine and therapeutic discoveries.
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影响因子：
7.5
作者：
Chen C;Hou J
通讯作者：
Hou J
DOI：
10.1002/adma.201501351
发表时间：
2015-07-15
期刊：
Advanced materials (Deerfield Beach, Fla.)
影响因子：
--
作者：
Celiz AD;Smith JG;Patel AK;Hook AL;Rajamohan D;George VT;Flatt L;Patel MJ;Epa VC;Singh T;Langer R;Anderson DG;Allen ND;Hay DC;Winkler DA;Barrett DA;Davies MC;Young LE;Denning C;Alexander MR
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Alexander MR
影响因子：
17.1
作者：
Bucaro, Michael A.;Vasquez, Yolanda;Aizenberg, Joanna
通讯作者：
Aizenberg, Joanna
影响因子：
41.2
作者：
Chaudhuri O;Gu L;Klumpers D;Darnell M;Bencherif SA;Weaver JC;Huebsch N;Lee HP;Lippens E;Duda GN;Mooney DJ
通讯作者：
Mooney DJ
DOI：
10.1073/pnas.1214100110
发表时间：
2013-06-18
影响因子：
11.1
作者：
Bian, Liming;Guvendiren, Murat;Burdick, Jason A.
通讯作者：
Burdick, Jason A.