Acid-sensing ion channels 3: a potential therapeutic target for pain treatment in arthritis
Acid-sensing ion channels 3: a potential therapeutic target for pain treatment in arthritis
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酸敏感离子通道 3：关节炎疼痛治疗的潜在治疗靶点
DOI：
10.1007/s11033-009-9907-6
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发表时间：
2010-10
影响因子：
2.8
通讯作者：
Li, Xia
中科院分区：
文献类型：
--
作者：
Yuan, Feng-Lai;Chen, Fei-Hu;Lu, Wei-Guo;Li, Xia
Acid-sensing ion channels 3 (ASIC3) is the most sensitive to such a pH change, predominantly distributed in the sensory peripheral nervous system, and strongly correlated with pain. Recently, there is increasing evidence that ASIC3 may contribute to the pathogenesis of chronic inflammatory pain diseases due to it is predominantly expressed in dorsal root ganglia (DRG) neurons making it a good candidate for a pain sensor. Elevated expression of ASIC3 was found in DRG of rodents with inflamed hind paws. In addition, it has been shown that ASIC3 gene knock-out mice (ASIC3−/−) exhibited no enhanced hyperalgesia in inflamed joint. All theses findings suggest that ASIC3 have important biological effects in inflammation that might be a promising therapeutic target for arthritis pain. In this review, we will briefly discuss the biological features of ASIC3 and summarize recent advances on the role of ASIC3 in the pathogenesis and treatment of arthritis pain.
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影响因子：
7.6
作者：
R. Ambalavanar;D. Dessem
通讯作者：
R. Ambalavanar;D. Dessem
DOI：
10.1097/00042737-200108000-00003
发表时间：
2001-08
影响因子：
2.1
作者：
Y. Yiangou;P. Facer;Jacqueline A. M. Smith;L. Sangameswaran;R. Eglen;R. Birch;C. Knowles;N. Williams;P. Anand
通讯作者：
Y. Yiangou;P. Facer;Jacqueline A. M. Smith;L. Sangameswaran;R. Eglen;R. Birch;C. Knowles;N. Williams;P. Anand
DOI：
10.1016/j.bbrc.2005.09.054
发表时间：
2005-11-11
影响因子：
3.1
作者：
Jahr, H;van Driel, M;van Leeuwen, JPTM
通讯作者：
van Leeuwen, JPTM
影响因子：
1.8
作者：
Sucher, NJ;Lipton, SA;Dreyer, EB
通讯作者：
Dreyer, EB
影响因子：
11.4
作者：
Deval, Emmanuel;Noel, Jacques;Lingueglia, Eric
通讯作者：
Lingueglia, Eric