Brain Macrophages: Close or Distant Relatives?
Brain Macrophages: Close or Distant Relatives?
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脑巨噬细胞：近亲还是远亲？
DOI：
10.1007/s12264-020-00595-3
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Gao Zhihua
中科院分区：
文献类型：
--
作者：
Cao Kelei;Hu Yaling;Gao Zhihua
The concept of a mononuclear phagocyte system in which tissue-resident macrophages arise from the circulating monocytes has been dogma in immunology for more than half a century [1]. While monocytes do give rise to macrophages under certain conditions, recent studies clearly demonstrate that monocytes do not primarily contribute to most adult tissue-resident macrophage pools under the steady state [2]. Instead, the majority of adult tissue-resident macrophages are derived from erythromyeloid progenitors (EMPs) in the yolk sac that seed tissue before birth [2].The brain governs our recognition, emotion, and behavior. Macrophages help to maintain brain homeostasis and ensure normal function. With regard to brain macrophages, microglia, the parenchymal resident macrophages, come to mind. Other than microglia, however, the brain also contains non-parenchymal border-associated macrophages (BAMs) that reside in the choroid plexus, meninges, and perivascular spaces [3]. While microglia adopt a typical ramified morphology with thin motile processes, BAMs appear to be amoeboid-like. Unlike the well-characterized origin of microglia from the yolk sac [2], the origin of BAMs had been obscure. Due to their differences in morphology and residence, microglia and BAMs were long thought to be two ontogenetically and transcriptionally distinct myeloid populations [4]. Until recently, studies demonstrated that microglia and BAMs are closely related
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影响因子：
30.5
作者：
Goldmann T;Wieghofer P;Jordão MJ;Prutek F;Hagemeyer N;Frenzel K;Amann L;Staszewski O;Kierdorf K;Krueger M;Locatelli G;Hochgerner H;Zeiser R;Epelman S;Geissmann F;Priller J;Rossi FM;Bechmann I;Kerschensteiner M;Linnarsson S;Jung S;Prinz M
通讯作者：
Prinz M
单核吞噬细胞的起源和动力学。
影响因子：
15.3
作者：
van Furth, R;Cohn, Z A
通讯作者：
Cohn, Z A
影响因子：
25
作者：
Van Hove, Hannah;Martens, Liesbet;Movahedi, Kiavash
通讯作者：
Movahedi, Kiavash
影响因子：
16.6
作者：
Rojo, Rocio;Raper, Anna;Pridans, Clare
通讯作者：
Pridans, Clare
影响因子：
25
作者：
Butovsky, Oleg;Jedrychowski, Mark P.;Moore, Craig S.;Cialic, Ron;Lanser, Amanda J.;Gabriely, Galina;Koeglsperger, Thomas;Dake, Ben;Wu, Pauline M.;Doykan, Camille E.;Fanek, Zain;Liu, LiPing;Chen, Zhuoxun;Rothstein, Jeffrey D.;Ransohoffl, Richard M.;Gygi, Steven P.;Antel, Jack P.;Weiner, Howard L.
通讯作者：
Weiner, Howard L.