Viral and immunological markers of HIV-associated Kaposi sarcoma recurrence.
Viral and immunological markers of HIV-associated Kaposi sarcoma recurrence.
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DOI：
10.1371/journal.pone.0254177
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Vally F
中科院分区：
文献类型：
--
作者：
Ngalamika O;Mukasine MC;Kawimbe M;Vally F
卡波西肉瘤 (KS) 是一种在撒哈拉以南非洲地区非常流行的艾滋病定义的血管增殖性恶性肿瘤。本研究的主要目的是确定与 HIV 相关 KS 复发相关的因素。我们招募了一组接受抗逆转录病毒治疗的患者，这些患者在接受细胞毒性癌症化疗后，艾滋病毒相关的 KS 已得到缓解。收集的变量包括社会人口统计学和临床参数、细胞因子和趋化因子、HIV 病毒载量和 CD4 计数。与 KS 复发的个体相比，持续缓解的个体在随访时 IL-5 显着升高（22.7pg/ml vs. 2.4pg/ml；p = 0.02）；在持续缓解的个体中，IL-6 在基线和随访时显着较高，分别为（18.4pg/ml vs. 0pg/ml；p = 0.01）和（18.0pg/ml vs. 0.18pg/ml；p = 0.03）；在持续缓解的个体中，IP-10 在基线和随访时显着降低，分别为（534pg/ml vs. 920pg/ml；p = 0.04）和（446pg/ml vs.1098pg/ml；p = 0.01）；而持续缓解的个体的 HIV 病毒载量在基线和随访时均显着降低（0 拷贝/毫升 vs 113 拷贝/毫升；p = 0.004）和（0 拷贝/毫升 vs 152 拷贝/毫升；p = 0.025）。血浆 IL-5、IL-6 和 IP-10 水平与 HIV 相关 KS 的复发相关，而持续检测到的 HIV 病毒载量会增加 KS 复发的风险。
Kaposi sarcoma (KS) is an AIDS-defining angio-proliferative malignancy highly prevalent in Sub-Saharan Africa. The main objective of this study was to determine the factors associated with recurrence of HIV-associated KS. We recruited a cohort of individuals on antiretroviral therapy who were in remission for HIV-associated KS after undergoing cytotoxic cancer chemotherapy. Collected variables included sociodemographic and clinical parameters, cytokines and chemokines, HIV viral loads, and CD4 counts. Compared to individuals who had KS recurrence, IL-5 was significantly higher at time of follow-up in individuals who had sustained remission (22.7pg/ml vs. 2.4pg/ml; p = 0.02); IL-6 was significantly higher at baseline and time of follow-up in individuals who had sustained remission, (18.4pg/ml vs. 0pg/ml; p = 0.01) and (18.0pg/ml vs. 0.18pg/ml; p = 0.03) respectively; IP-10 was significantly lower at baseline and at time of follow-up in individuals who had sustained remission, (534pg/ml vs. 920pg/ml; p = 0.04) and (446pg/ml vs.1098pg/ml; p = 0.01) respectively; while HIV viral load was significantly lower at baseline and at time of follow-up in individuals who had sustained remission, (0copies/ml vs. 113copies/ml; p = 0.004) and (0copies/ml vs. 152copies/ml; p = 0.025) respectively. Plasma levels of IL-5, IL-6, and IP-10 are associated with recurrence of HIV-associated KS, while persistently detectable HIV viral loads increase the risk of KS recurrence.
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影响因子：
15.9
作者：
Fisher, Daniel T.;Chen, Qing;Evans, Sharon S.
通讯作者：
Evans, Sharon S.
影响因子：
1.8
作者：
Damtie D;Yismaw G;Woldeyohannes D;Anagaw B
通讯作者：
Anagaw B
IL-6的两个面在肿瘤微环境中。
影响因子：
7.8
作者：
Fisher DT;Appenheimer MM;Evans SS
通讯作者：
Evans SS
影响因子：
--
作者：
Mocroft, A;Youle, M;Gazzard, B
通讯作者：
Gazzard, B
影响因子：
3.7
作者：
Ngalamika, Owen;Tso, For Yue;West, John
通讯作者：
West, John