RANTES release by human adipose tissue in vivo and evidence for depot-specific differences.
RANTES release by human adipose tissue in vivo and evidence for depot-specific differences.
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DOI：
10.1152/ajpendo.90511.2008
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发表时间：
2009-06
期刊：
影响因子：
--
通讯作者：
Mohamed-Ali V
中科院分区：
文献类型：
--
作者：
Madani R;Karastergiou K;Ogston NC;Miheisi N;Bhome R;Haloob N;Tan GD;Karpe F;Malone-Lee J;Hashemi M;Jahangiri M;Mohamed-Ali V
肥胖与来自各种脂肪组织库的升高的炎症信号相关。本研究的目的是评价人体脂肪组织在体内和离体释放的调节活化的正常T细胞表达和分泌的（RANTES），参照单核细胞趋化蛋白-1（MCP-1）和白细胞介素-6（IL-6）的释放。RANTES、MCP-1和IL-6的动静脉差异在具有广泛肥胖的健康高加索受试者的腹部皮下脂肪组织中进行了体内研究。在病态肥胖减肥手术患者的腹部皮下、胃脂肪垫和网膜脂肪组织以及无冠状动脉疾病的心脏手术患者的胸部皮下和心外膜脂肪组织中研究了全身水平和离体RANTES释放。动静脉研究证实了在瘦和肥胖受试者的脂肪组织中体内RANTES和IL-6的释放以及在肥胖中MCP-1的释放。然而，MCP-1和RANTES的体内释放，而不是IL-6，低于循环水平。与网膜（P = 0.01）和皮下（P = 0.001）组织相比，RANTES从胃脂肪垫的体外释放更大。在瘦型受试者中，心外膜脂肪组织释放的RANTES少于胸部皮下脂肪组织（P = 0.04），但不包括肥胖受试者。肥胖指数与心外膜RANTES相关，但与全身RANTES或其从其他仓库释放无关。总之，RANTES在体内由人皮下脂肪组织释放，在体外由其他贮库以不同的量释放。虽然脂肪器官似乎不太可能显著影响循环水平，但这种趋化因子的局部影响值得进一步研究。
Obesity is associated with elevated inflammatory signals from various adipose tissue depots. This study aimed to evaluate release of regulated on activation, normal T cell expressed and secreted (RANTES) by human adipose tissue in vivo and ex vivo, in reference to monocyte chemoattractant protein-1 (MCP-1) and interleukin-6 (IL-6) release. Arteriovenous differences of RANTES, MCP-1, and IL-6 were studied in vivo across the abdominal subcutaneous adipose tissue in healthy Caucasian subjects with a wide range of adiposity. Systemic levels and ex vivo RANTES release were studied in abdominal subcutaneous, gastric fat pad, and omental adipose tissue from morbidly obese bariatric surgery patients and in thoracic subcutaneous and epicardial adipose tissue from cardiac surgery patients without coronary artery disease. Arteriovenous studies confirmed in vivo RANTES and IL-6 release in adipose tissue of lean and obese subjects and release of MCP-1 in obesity. However, in vivo release of MCP-1 and RANTES, but not IL-6, was lower than circulating levels. Ex vivo release of RANTES was greater from the gastric fat pad compared with omental (P = 0.01) and subcutaneous (P = 0.001) tissue. Epicardial adipose tissue released less RANTES than thoracic subcutaneous adipose tissue in lean (P = 0.04) but not obese subjects. Indexes of obesity correlated with epicardial RANTES but not with systemic RANTES or its release from other depots. In conclusion, RANTES is released by human subcutaneous adipose tissue in vivo and in varying amounts by other depots ex vivo. While it appears unlikely that the adipose organ contributes significantly to circulating levels, local implications of this chemokine deserve further investigation.
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影响因子：
4.8
作者：
Sacks, Harold S.;Fain, John N.
通讯作者：
Fain, John N.
影响因子：
37.8
作者：
Mazurek, T;Zhang, LF;Shi, Y
通讯作者：
Shi, Y
影响因子：
5.8
作者：
Huber, Joakim;Kiefer, Florian W.;Stulnig, Thomas M.
通讯作者：
Stulnig, Thomas M.
影响因子：
6
作者：
FRAYN, KN;COPPACK, SW;WHYTE, PL
通讯作者：
WHYTE, PL
DOI：
10.1089/109264203322333584
发表时间：
2003-08-01
期刊：
JOURNAL OF LAPAROENDOSCOPIC & ADVANCED SURGICAL TECHNIQUES-PART A
影响因子：
--
作者：
Ren, CJ;Fielding, GA
通讯作者：
Fielding, GA