Physical inactivity and idiopathic pulmonary embolism in women: prospective study.
Physical inactivity and idiopathic pulmonary embolism in women: prospective study.
复制标题
DOI：
10.1136/bmj.d3867
复制
发表时间：
2011-07-04
期刊：
影响因子：
--
通讯作者：
Camargo CA Jr
中科院分区：
文献类型：
--
作者：
Kabrhel C;Varraso R;Goldhaber SZ;Rimm E;Camargo CA Jr
目的确定缺乏运动(即久坐不动的生活方式)与特发性肺栓塞事件之间的关系。设计前瞻性队列研究。设置护士健康研究室。研究对象为69 950名女性护士，完成1990-2008两年一次的问卷调查。主要观察指标主要结果为特发性肺栓塞，已在病历中得到证实。控制年龄、体重指数(BMI)、能量摄入、吸烟、背包年限、种族、配偶的教育程度、产次、更年期、非阿司匹林、非类固醇抗炎药、华法林、多种维生素补充剂、高血压、冠心病、风湿病和饮食模式的多变量Cox比例风险模型。主要的暴露是缺乏身体活动，以每天坐着的小时数衡量。第二次接触是体力活动，以每天的代谢量衡量。结果在18年的研究期间，共发生特发性肺栓塞268例。坐着的时间与特发性肺栓塞的风险有关(在联合资料中，最不活跃的41/104720v16/14565例；趋势P<；0.001)。久坐时间最长的女性发生肺血栓的风险是久坐时间最少女性的两倍多(多变量风险比为2.34，95%可信区间为1.30-4.20)。体力活动与肺栓塞无相关性(趋势P=0.53)。结论体力活动不足与女性肺栓塞的发生有关。减少坐着时间的干预可以降低肺血栓的风险。
Objectives To determine the association between physical inactivity (that is, a sedentary lifestyle) and incident idiopathic pulmonary embolism. Design Prospective cohort study. Setting Nurses’ Health Study. Participants 69 950 female nurses who completed biennial questionnaires from 1990 to 2008. Main outcome measures The primary outcome was idiopathic pulmonary embolism confirmed in medical records. Multivariable Cox proportional hazards models controlled for age, body mass index (BMI), energy intake, smoking, pack years, race, spouse’s educational attainment, parity, menopause, non-aspirin non-steroidal anti-inflammatory drugs, warfarin, multivitamin supplements, hypertension, coronary heart disease, rheumatological disease, and dietary patterns. The primary exposure was physical inactivity, measured in hours of sitting each day. The secondary exposure was physical activity, measured in metabolic equivalents a day. Results Over the 18 year study period, there were 268 cases of incident idiopathic pulmonary embolism. There was an association between time of sitting and risk of idiopathic pulmonary embolism (41/104 720 v 16/14 565 cases in most inactive v least inactive in combined data; P<0.001 for trend). The risk of pulmonary embolism was more than twofold in women who spent the most time sitting compared with those who spent the least time sitting (multivariable hazard ratio 2.34, 95% confidence interval 1.30 to 4.20). There was no association between physical activity and pulmonary embolism (P=0.53 for trend). Conclusions Physical inactivity is associated with incident pulmonary embolism in women. Interventions that decrease time sitting could lower the risk of pulmonary embolism.
登录
查看更多内容
DOI：
10.1302/0301-620x.81b4.8909
发表时间：
1999-07-01
影响因子：
--
作者：
Sochart, DH;Hardinge, K
通讯作者：
Hardinge, K
影响因子：
120.7
作者：
Goldhaber, SZ;Grodstein, F;Hennekens, CH
通讯作者：
Hennekens, CH
影响因子：
6.7
作者：
Kucher, N;Tapson, VF;Goldhaber, SZ
通讯作者：
Goldhaber, SZ
影响因子：
--
作者：
Jackson, Andrew S.;Sui, Xuemei;Blair, Steven N.
通讯作者：
Blair, Steven N.
影响因子：
10.4
作者：
Heit, JA
通讯作者：
Heit, JA