TRPA1: An asthma target with a zing.
TRPA1: An asthma target with a zing.
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DOI：
10.1084/jem.20202507
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发表时间：
2021-04-05
期刊：
影响因子：
--
通讯作者：
Jordt SE
中科院分区：
文献类型：
--
作者：
Jordt SE
A significant number of patients respond poorly to current asthma interventions. Balestrini et al. advance the concept that sensory nerves control inflammation in asthma, demonstrating that a novel inhibitor of TRPA1, a chemical irritant receptor, suppresses asthmatic inflammation in several preclinical species. Asthma therapy has advanced remarkably; however, a significant number of patients respond poorly to current interventions. Balestrini et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201637) advance the concept that sensory nerves control inflammation in asthma, demonstrating that a novel inhibitor of TRPA1, a nerve receptor for irritants and reactive endogenous mediators, suppresses inflammation and airway smooth muscle contraction in several preclinical species.
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