Quantifying over-activity in bipolar and schizophrenia patients in a human open field paradigm.
Quantifying over-activity in bipolar and schizophrenia patients in a human open field paradigm.
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DOI：
10.1016/j.psychres.2010.04.032
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发表时间：
2010-06-30
影响因子：
11.3
通讯作者：
Geyer, Mark A.
中科院分区：
文献类型：
--
作者：
Perry, William;Minassian, Arpi;Henry, Brook;Kincaid, Meegin;Young, Jared W.;Geyer, Mark A.
有人认为，躁狂的一个主要症状是过度活动和夸张的目标导向型行为。然而，很少有人尝试在实验室环境中客观地量化这种行为。有一种可靠的方法来评估过度活动可能有助于区分躁狂双相情感障碍(BD)和精神分裂症(SCZ)在高激活状态下。在目前的研究中，使用多变量方法评估了对象-交互作用的可量化测量。此外，还对过度活动的相关症状进行了评估。BD伴躁狂症或SCZ(偏执狂和非偏执狂亚型)以及非患者对照(NC)的患者因BD伴躁狂症或SCZ(偏执狂和非偏执狂亚型)而住进急性护理精神病院，他们在被称为人类行为模式监测器(HBPM)的开放领域环境中进行评估。通过隐蔽摄像机记录15分钟的活动和与新事物的互动，并对探索性行为进行评级。与NC相比，BD和SCZ患者在接近物体上花费的时间更多，总体行走时间也更多。相比之下，与SCZ患者或NC参与者相比，BD患者表现出更多与对象的身体接触(对象交互次数和与对象相处的时间)，以及更坚持不懈和社交去抑制的行为，这表明了一种独特的过度活动和目标导向行为模式。进一步的分析显示，SCZ患者之间根据他们的亚型存在差异。目前的研究扩展了我们在受控实验室环境中量化探索和过度活动的方法，并有助于评估BD和SCZ的重叠和区分特征。
It has been suggested that a cardinal symptom of mania is over-activity and exaggerated goal-directed behavior. Nevertheless, few attempts have been made to quantify this behavior objectively in a laboratory environment. Having a methodology to assess over-activity reliably might be useful in distinguishing manic bipolar disorder (BD) from schizophrenia (SCZ) during highly activated states. In the current study, quantifiable measures of object-interaction were assessed using a multivariate approach. Additionally, symptom correlates of over-activity were assessed. Patients admitted to an acute care psychiatric hospital for either BD with mania or SCZ (paranoid and non-paranoid subtypes) as well as non-patient comparison (NC) participants were assessed in an open field setting referred to as the human Behavioral Pattern Monitor (hBPM). Activity and interactions with novel and engaging objects were recorded for 15 minutes via a concealed video camera and rated for exploratory behavior. Both BD and SCZ patients spent more time near the objects and exhibited more overall walking compared to NC. In contrast, BD patients exhibited greater physical contact with objects (number of object interactions and time spent with objects) relative to SCZ patients or NC participants, as well as more perseverative and socially disinhibited behaviors, indicating a unique pattern of over-activity and goal-directed behavior. Further analyses revealed a distinction between SCZ patients according to their subtype. The current study extends our methodology for quantifying exploration and over-activity in a controlled laboratory setting and aids in assessing the overlap and distinguishing characteristics of BD and SCZ.
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