Tumor microenvironment as a therapeutic target in cancer.
Tumor microenvironment as a therapeutic target in cancer.
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肿瘤微环境作为癌症的治疗靶点。
DOI：
10.1016/j.pharmthera.2020.107753
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发表时间：
2021-05
影响因子：
13.5
通讯作者：
Yu D
中科院分区：
文献类型：
--
作者：
Xiao Y;Yu D
Tumor microenvironment denotes the non-cancerous cells and components presented in the tumor, including molecules produced and released by them. The constant interactions between tumor cells and the tumor microenvironment play decisive roles in tumor initiation, progression, metastasis, and response to therapies. The tumor microenvironment as a therapeutic target in cancer has attracted great research and clinical interest. Here we summarize the current progress in targeting the tumor microenvironment in both drug development and clinical trials; highlight challenges in targeting the tumor microenvironment to achieve therapeutic efficacy; explore new technologies and approaches to better decipher the tumor microenvironment; and discuss strategies to intervene in the pro-tumor microenvironment and maximize therapeutic benefits.
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影响因子：
11.2
作者：
Anderberg C;Li H;Fredriksson L;Andrae J;Betsholtz C;Li X;Eriksson U;Pietras K
通讯作者：
Pietras K
DOI：
10.1158/1078-0432.ccr-16-3122
发表时间：
2017-07-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Brown JM;Recht L;Strober S
通讯作者：
Strober S
DOI：
10.1158/1078-0432.ccr-18-1955
发表时间：
2019-04-01
期刊：
Clinical cancer research : an official journal of the American Association for Cancer Research
影响因子：
--
作者：
Bernard V;Semaan A;Huang J;San Lucas FA;Mulu FC;Stephens BM;Guerrero PA;Huang Y;Zhao J;Kamyabi N;Sen S;Scheet PA;Taniguchi CM;Kim MP;Tzeng CW;Katz MH;Singhi AD;Maitra A;Alvarez HA
通讯作者：
Alvarez HA
影响因子：
3.7
作者：
Anand, Preetha;Kunnumakara, Ajaikumar B.;Sundaram, Chitra;Harikumar, Kuzhuvelil B.;Tharakan, Sheeja T.;Lai, Oiki S.;Sung, Bokyung;Aggarwal, Bharat B.
通讯作者：
Aggarwal, Bharat B.
DOI：
10.1634/theoncologist.2017-0024
发表时间：
2017-03
期刊：
The oncologist
影响因子：
--
作者：
Benson AB 3rd;Wainberg ZA;Hecht JR;Vyushkov D;Dong H;Bendell J;Kudrik F
通讯作者：
Kudrik F