Intergenerational Transmission of Frontal Alpha Asymmetry Among Mother-Infant Dyads.
Intergenerational Transmission of Frontal Alpha Asymmetry Among Mother-Infant Dyads.
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DOI：
10.1016/j.bpsc.2019.12.003
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发表时间：
2020-04
期刊：
影响因子：
--
通讯作者：
Foti D
中科院分区：
文献类型：
--
作者：
Hill KE;Neo WS;Hernandez A;Hamrick LR;Kelleher BL;Foti D
额叶α不对称（FAA）是抑郁风险的一个公认的神经生物学指标。FAA降低与成年人当前和缓解的抑郁症有关，并且在三个月大的抑郁症母亲的后代中可见，这表明抑郁症风险的潜在传播机制。然而，尚不清楚FAA是否与家庭直接相关。为了解决这一差距，我们评估了FAA的代际传播的非临床队列的母婴二对。母亲和他们的12个月大的婴儿（N=34对）完成平行的静息状态任务，而脑电图记录。我们测量了FAA在一系列假定的频带，并计算其可靠性的母亲和婴儿。最后，根据亲子相关分析，对FAA的遗传力进行了评估。母亲和婴儿的FAA会聚在母亲的高α范围（11-13 Hz）和婴儿的宽α范围（6-9 Hz）中最强。母亲高FAA在80秒后表现出极好的分半信度（rSB= 0.99）和内部一致性（α= 0.90）;婴儿FAA在70秒后表现出良好的分半信度（rSB= 0.81）和一般的内部一致性（α= 0.74）。母婴FAA中度相关（r= 0.41），这表明狭义遗传率高达82%。FAA可以在成人和婴儿中进行可靠且相对快速的评估。有一个强大的关联FAA之间的母亲和他们的婴儿，支持代际传递。这与FAA降低可能直接在个体家庭水平上赋予抑郁风险的可能性一致。
Frontal alpha asymmetry (FAA) is a well-established neurobiological indicator of depression risk. Reduced FAA relates to current and remitted depression in adults, and is seen in offspring of mothers with depression as young as three months, suggesting a potentially transmittable mechanism of depression risk. It is unclear, however, whether FAA is directly associated within families. To address this gap, we evaluated the intergenerational transmission of FAA in a non-clinical cohort of mother-infant dyads. Mothers and their 12-month-old infants (N=34 dyads) completed parallel resting-state tasks while EEG was recorded. We measured FAA across a range of putative frequency bands and calculated its reliability in mothers and infants. Finally, we evaluated the heritability of FAA based on the parent-offspring correlation. Mother and infant FAA convergence was strongest in the high alpha range for mothers (11–13 Hz) and broad alpha range for infants (6–9 Hz). Mother high FAA exhibited excellent split-half reliability (rSB=.99) and internal consistency after 80 seconds (α=.90); infant FAA exhibited good split-half reliability (rSB=.81) and fair internal consistency after 70 seconds (α=.74). Mother-infant FAA were moderately correlated (r=.41), which indicates narrow-sense heritability of up to 82%. FAA can be assessed reliably and relatively quickly in both adults and infants. There is a robust association of FAA between mothers and their infants, supporting intergenerational transmission. This is consistent with the possibility that reduced FAA may directly confer depression risk at the individual family level.
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