Movement-Modulation of Local Power and Phase Amplitude Coupling in Bilateral Globus Pallidus Interna in Parkinson Disease.
Movement-Modulation of Local Power and Phase Amplitude Coupling in Bilateral Globus Pallidus Interna in Parkinson Disease.
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DOI：
10.3389/fnhum.2018.00270
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发表时间：
2018
影响因子：
2.9
通讯作者：
Pouratian N
中科院分区：
文献类型：
--
作者：
AuYong N;Malekmohammadi M;Ricks-Oddie J;Pouratian N
有证据表明，双侧基底神经节运动网络共同支持正常的运动行为，包括单侧运动。这些网络在侧化运动中相互作用的程度和方式尚不清楚。在这项研究中，同时记录双侧苍白球（GPi）的内部（LFP）的局部场电位（LFP）检查19例原发性帕金森病（PD），而接受清醒的脑深部电刺激（DBS）植入。在两种行为状态下进行记录;休息和暗示左手运动（手指敲击）。研究了不同状态对α- β振荡功率和β相位编码的相位振幅耦合（PAC）的影响，包括半球间对称和非对称的变化。单侧手部运动导致双侧GPi在α（8-12 Hz）和高β（21-35 Hz）处的对称振荡功率抑制以及高频振荡（HFO，200-300 Hz）频带的功率增加。在对侧GPi内的低β（13-20 Hz）和低γ（40-80 Hz）频段也观察到不对称衰减（P = 0.009）。单侧运动对PAC的影响仅限于对侧GPi，低β-低γ和β-HFO PAC均减弱（P < 0.05）。进一步分析表明，低β和低γ功率的偏侧衰减与低β-低γ PAC变化无关。双侧GPi之间的整体一致性并未因单侧运动而发生显着改变，但高β范围内的首选相位差从休息期间的0.23（±1.31）弧度增加到运动执行期间的1.99（±0.78）弧度。总之，目前的研究结果表明，单侧运动控制涉及双边基底神经节网络的运动功能不同的频带编码。低β和低γ衰减随运动的偏侧化表明，这些频带是运动行为特有的，而α、高β和HFO振荡的对称表达最好对应于运动状态。运动相关的PAC调制对侧GPi的限制表明，交叉频率的相互作用似乎与偏侧运动。尽管没有显着的运动相关的变化，在半球间的连贯性，相位差的增加表明，双边GPi之间的通信改变了与单方面的运动。
There is converging evidence that bilateral basal ganglia motor networks jointly support normal movement behaviors including unilateral movements. The extent and manner in which these networks interact during lateralized movement remains unclear. In this study, simultaneously recorded bilateral Globus Pallidus interna (GPi) local field potentials (LFP) were examined from 19 subjects with idiopathic Parkinson disease (PD), while undergoing awake deep brain stimulation (DBS) implantation. Recordings were carried out during two behavioral states; rest and cued left hand movement (finger tapping). The state-dependent effects on α- β oscillatory power and β phase-encoded phase amplitude coupling (PAC), including symmetrical and assymetrical changes between hemispheres, were identified. Unilateral hand movement resulted in symmetrical oscillatory power suppression within bilateral GPi at α (8–12 Hz) and high β (21–35 Hz) and increase in power of high frequency oscillations (HFO, 200–300 Hz) frequency bands. Asymmetrical attenuation was also observed at both low β (13–20 Hz) and low γ (40–80 Hz) bands within the contralateral GPi (P = 0.009). In addition, unilateral movement effects on PAC were confined to the contralateral GPi with attenuation of both low β-low γ and β-HFO PAC (P < 0.05). Further analysis showed that the lateralized attenuation of low β and low γ power did not correlate with low β-low γ PAC changes. The overall coherence between bilateral GPi was not significantly altered with unilateral movement, however the preferred phase difference in the high β range increased from 0.23 (±1.31) radians during rest to 1.99 (±0.78) radians during movement execution. Together, the present results suggest that unilateral motor control involves bilateral basal ganglia networks with movement features differentially encoded by distinct frequency bands. The lateralization of low β and low γ attenuation with movement suggests that these frequency bands are specific to the motor act whereas symmetrical expression of α, high β, and HFO oscillations best correspond to motor state. The restriction of movement-related PAC modulation to the contralateral GPi indicates that cross-frequency interactions appear to be associated with lateralized movements. Despite no significant movement-related changes in the interhemispheric coherence, the increase in phase difference suggests that the communication between bilateral GPi is altered with unilateral movement.
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影响因子：
5.3
作者：
de Solages, Camille;Hill, Bruce C.;Bronte-Stewart, Helen
通讯作者：
Bronte-Stewart, Helen
影响因子：
3.7
作者：
Avanzini P;Fabbri-Destro M;Dalla Volta R;Daprati E;Rizzolatti G;Cantalupo G
通讯作者：
Cantalupo G
影响因子：
5.3
作者：
Avila, Irene;Parr-Brownlie, Louise C.;Brazhnik, Elena;Castaneda, Edward;Bergstrom, Debra A.;Walters, Judith R.
通讯作者：
Walters, Judith R.
DOI：
10.1111/ejn.12574
发表时间：
2014-06
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Brittain JS;Sharott A;Brown P
通讯作者：
Brown P
影响因子：
8.6
作者：
Cincotta, Massimo;Giovannelli, Fabio;Ziemann, Ulf
通讯作者：
Ziemann, Ulf