Morbidity risks among older adults with pre-existing age-related diseases.
Morbidity risks among older adults with pre-existing age-related diseases.
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DOI：
10.1016/j.exger.2013.09.005
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发表时间：
2013-12
影响因子：
3.9
通讯作者：
Yashin, Anatoliy I.
中科院分区：
文献类型：
--
作者：
Akushevich, Igor;Kravchenko, Julia;Ukraintseva, Svetlana;Arbeev, Konstantin;Kulminski, Alexander;Yashin, Anatoliy I.
多种发病率在老年人中很常见;然而，对于许多与衰老相关的疾病，美国老年人群没有关于早期表现的疾病如何影响患者一生中后期表现的另一种疾病风险的信息。使用与医疗保险服务使用文件（MFSU）相关的监测、流行病学和最终结果（SEER）登记数据，对患有既存疾病的老年人的癌症和非癌症疾病风险进行定量评估。使用包含2，154，598人的个人记录的SEER-Medicare数据，我们经验性地评估了在早期表现的疾病发作后诊断的年龄相关疾病的发病率的年龄模式，并将这些模式与一般人群进行了比较。使用MFSU中编码的诊断信息、医疗服务/程序日期和Medicare登记/退出信息重建个人病史。观察到15种疾病对的后续疾病风险增加了三倍以上，其中大多数是i）相同器官和/或系统的疾病（例如，对于阿尔茨海默病患者，帕金森病，HR=3.77，对于肾衰竭患者，肾癌，HR=3.28）或ii）原发疾病为快速进展性癌症的疾病对（即，肺、肾和胰腺），例如，胰腺癌患者中，溃疡（HR=4.68）和黑色素瘤（HR=4.15）。在20种疾病对中登记了后续疾病的较低风险，主要是阿尔茨海默病或帕金森病患者，例如，降低阿尔茨海默病（HR=0.64）和帕金森病（HR=0.60）患者的肺癌风险。在美国老年人中观察到老年疾病风险的协同和拮抗依赖性，确认已知的和检测广泛的年龄相关疾病的新关联。研究结果可用于优化美国老年人群慢性病的筛查、预防和治疗策略。
Multi-morbidity is common among older adults; however, for many aging-related diseases there is no information for U.S. elderly population on how earlier-manifested disease affects the risk of another disease manifested later during patient’s lifetime. Quantitative evaluation of risks of cancer and non-cancer diseases for older adults with pre-existing conditions is performed using the Surveillance, Epidemiology, and End Results (SEER) Registry data linked to the Medicare Files of Service Use (MFSU). Using the SEER-Medicare data containing individual records for 2,154,598 individuals, we empirically evaluated age patterns of incidence of age-associated diseases diagnosed after the onset of earlier manifested disease and compared these patterns with those in general population. Individual medical histories were reconstructed using information on diagnoses coded in MFSU, dates of medical services/procedures, and Medicare enrollment/disenrollment. More than threefold increase of subsequent diseases risk was observed for 15 disease pairs, majority of them were i) diseases of the same organ and/or system (e.g., Parkinson disease for patients with Alzheimer disease, HR=3.77, kidney cancer for patients with renal failure, HR=3.28) or ii) disease pairs with primary diseases being fast-progressive cancers (i.e., lung, kidney, and pancreas), e.g., ulcer (HR=4.68) and melanoma (HR=4.15) for patients with pancreatic cancer. Lower risk of subsequent disease was registered for 20 disease pairs, mostly among patients with Alzheimer’s or Parkinson’s disease, e.g., decreased lung cancer risk among patients with Alzheimer’s (HR=0.64) and Parkinson’s (HR=0.60) disease. Synergistic and antagonistic dependences in geriatric disease risks were observed among US elderly confirming known and detecting new associations of wide spectrum of age-associated diseases. The results can be used in optimization of screening, prevention and treatment strategies of chronic diseases among U.S. elderly population.
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影响因子：
16.2
作者：
Rajpathak SN;Kumbhani DJ;Crandall J;Barzilai N;Alderman M;Ridker PM
通讯作者：
Ridker PM
影响因子：
6.4
作者：
FARROW, DC;DAVIS, S
通讯作者：
DAVIS, S
影响因子：
4.1
作者：
Fiala, KH;Whetteckey, J;Manyam, BV
通讯作者：
Manyam, BV
DOI：
10.1093/jnci/djr531
发表时间：
2012-02-01
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
Fuhrman, Barbara J.;Schairer, Catherine;Ziegler, Regina G.
通讯作者：
Ziegler, Regina G.
影响因子：
7.8
作者：
Kulminski AM;Culminskaya I;Ukraintseva SV;Arbeev KG;Arbeeva L;Wu D;Akushevich I;Land KC;Yashin AI
通讯作者：
Yashin AI