A metabolic link to skeletal muscle wasting and regeneration.
A metabolic link to skeletal muscle wasting and regeneration.
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DOI：
10.3389/fphys.2014.00032
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发表时间：
2014
影响因子：
4
通讯作者：
Ryall JG
中科院分区：
文献类型：
--
作者：
Koopman R;Ly CH;Ryall JG
由于其在运动、隔离内脏、产生热量以维持核心体温以及作为主要能量储存库等方面的重要作用，骨骼肌结构和功能的任何损害都可能导致发病率和死亡率增加。就骨骼肌而言，代谢改变与许多病理和疾病直接相关，包括糖尿病和肥胖，而许多骨骼肌病理有代谢的继发变化，包括癌症恶病质、肌肉减少症和肌营养不良。此外，细胞代谢在骨骼肌干细胞调节中的重要性开始受到广泛关注。因此，很明显，骨骼肌代谢与骨骼肌质量和再生的调节有着复杂的联系。本综述的目的是讨论一些最近的发现，这些发现将新陈代谢的变化与骨骼肌质量的变化联系起来，并描述了最近在发育、癌症和干细胞生物学方面的一些研究，这些研究已经确定了细胞代谢在干细胞功能调节中的作用，这一过程被称为“代谢重编程”。
Due to its essential role in movement, insulating the internal organs, generating heat to maintain core body temperature, and acting as a major energy storage depot, any impairment to skeletal muscle structure and function may lead to an increase in both morbidity and mortality. In the context of skeletal muscle, altered metabolism is directly associated with numerous pathologies and disorders, including diabetes, and obesity, while many skeletal muscle pathologies have secondary changes in metabolism, including cancer cachexia, sarcopenia and the muscular dystrophies. Furthermore, the importance of cellular metabolism in the regulation of skeletal muscle stem cells is beginning to receive significant attention. Thus, it is clear that skeletal muscle metabolism is intricately linked to the regulation of skeletal muscle mass and regeneration. The aim of this review is to discuss some of the recent findings linking a change in metabolism to changes in skeletal muscle mass, as well as describing some of the recent studies in developmental, cancer and stem-cell biology that have identified a role for cellular metabolism in the regulation of stem cell function, a process termed “metabolic reprogramming.”
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影响因子：
7.4
作者：
Dodson, Matthew;Darley-Usmar, Victor;Zhang, Jianhua
通讯作者：
Zhang, Jianhua
影响因子：
11.8
作者：
Fulco, Marcella;Cen, Yana;Sartorelli, Vittorio
通讯作者：
Sartorelli, Vittorio
影响因子：
29
作者：
Folmes CD;Nelson TJ;Martinez-Fernandez A;Arrell DK;Lindor JZ;Dzeja PP;Ikeda Y;Perez-Terzic C;Terzic A
通讯作者：
Terzic A
DOI：
10.1126/science.1191035
发表时间：
2010-08-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Gilbert PM;Havenstrite KL;Magnusson KE;Sacco A;Leonardi NA;Kraft P;Nguyen NK;Thrun S;Lutolf MP;Blau HM
通讯作者：
Blau HM
影响因子：
21.3
作者：
Dellavalle, Arianna;Sampaolesi, Maurilio;Cossu, Giulio
通讯作者：
Cossu, Giulio