AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2.
AEBP2 as a potential targeting protein for Polycomb Repression Complex PRC2.
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DOI：
10.1093/nar/gkp149
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发表时间：
2009-05
影响因子：
14.9
通讯作者：
Kim J
中科院分区：
文献类型：
--
作者：
Kim H;Kang K;Kim J
AEBP 2是一种锌指蛋白，已被证明与哺乳动物多梳抑制复合物2（PRC 2）相互作用。在目前的研究中，我们对这种未知蛋白进行了表征，并测试了其对PRC 2的潜在靶向作用。AEBP 2是一个进化上高度保守的基因，存在于从飞行昆虫到哺乳动物的动物中。哺乳动物AEBP 2的转录由两个可选的启动子驱动，并产生至少两种蛋白质的同种型。这些亚型显示发育阶段特异性表达模式：成人特异性较大的形式（51 kDa）和胚胎特异性较小的形式（32 kDa）。AEBP 2蛋白与具有不寻常的二分结构的DNA结合基序结合，CTT（N）15- 23 cagGCC，小写不太重要。AEBP 2的大部分靶基因座也与PRC 2的已知靶基因座紧密映射。事实上，这些基因座中的许多基因座由两种蛋白质AEBP 2和SUZ 12共同占据。这表明AEBP 2最有可能是哺乳动物PRC 2复合物的靶向蛋白。
AEBP2 is a zinc finger protein that has been shown to interact with the mammalian Polycomb Repression Complex 2 (PRC2). In the current study, we characterized this unknown protein and tested its potential targeting roles for the PRC2. AEBP2 is an evolutionarily well-conserved gene that is found in the animals ranging from flying insects to mammals. The transcription of mammalian AEBP2 is driven by two alternative promoters and produces at least two isoforms of the protein. These isoforms show developmental stage-specific expression patterns: the adult-specific larger form (51 kDa) and the embryo-specific smaller form (32 kDa). The AEBP2 protein binds to a DNA-binding motif with an unusual bipartite structure, CTT(N)15-23cagGCC with lower-case being less critical. A large fraction of AEBP2's target loci also map closely to the known target loci of the PRC2. In fact, many of these loci are co-occupied by the two proteins, AEBP2 and SUZ12. This suggests that AEBP2 is most likely a targeting protein for the mammalian PRC2 complex.
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