Ki-67 is a prognostic biomarker of survival after radiofrequency ablation of liver malignancies.
Ki-67 is a prognostic biomarker of survival after radiofrequency ablation of liver malignancies.
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DOI：
10.1245/s10434-012-2461-9
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发表时间：
2012-12
影响因子：
3.7
通讯作者：
Kemeny NE
中科院分区：
文献类型：
--
作者：
Sofocleous CT;Garg S;Petrovic LM;Gonen M;Petre EN;Klimstra DS;Solomon SB;Brown KT;Brody LA;Covey AM;Dematteo RP;Schwartz L;Kemeny NE
目的：评价肝肿瘤射频消融术(RFA)后局部无进展生存期(LPFS)和总生存期(OS)的预测价值。一项机构审查委员会批准的、符合《健康保险可携带性和责任法案》的审查确定了63名患者中68例接受RFA治疗的肝脏肿瘤，并进行了至少3年的随访。用增殖(Ki-67)和凋亡(caspase-3)标记物评价肝肿瘤射频消融术后组织的黏附情况。LPFS和OS采用Kaplan-Meier方法和对数等级检验进行评价。多变量分析评估了肿瘤大小、病理和RFA术后组织特征对LPFS和OS的影响。组织学检查显示，68例肿瘤中有55例完全消融并凝固性坏死，caspase-3阳性，Ki-67(CN)阴性。13例肿瘤细胞呈Ki-67阳性。存活(V)组的平均肝肿瘤大小大于CN组(分别为3.4 cm和2.5 cm；P=0.017)。对于V组和CN组，局部肿瘤进展分别发生在12例(92%)和23例(42%)55例标本中。V组和CN组的1年、3年和5年LPFS分别为8%、8%和8%，以及79%、47%和47%(P<；.001)。在63个月的中位随访期间，V组和CN组分别有92%和58%的患者死亡，导致1年、3年和5年的OS分别为92%、25%和8%，而分别为92%、59%和33%(P=.032)。肝肿瘤射频消融术后电极上Ki-67阳性的肿瘤细胞是LPFS和OS的独立预测因子。大小最初被认为是肿瘤局部进展的独立危险因素，在3-5厘米的肿瘤中，在长期随访中并不具有重要意义。
To assess the predictive value of examinations of tissue adherent to multitined electrodes on local tumor progression-free survival (LPFS) and overall survival (OS) after liver tumor radiofrequency ablation (RFA). An institutional review board–approved, Health Insurance Portability and Accountability Act–compliant review identified 68 liver tumors treated with RFA in 63 patients with at least 3 years’ follow-up. Tissue adherent to the electrode after liver tumor RFA was evaluated with proliferation (Ki-67) and apoptotic (caspase-3) markers. LPFS and OS were evaluated by Kaplan–Meier methodology and the log-rank test. Multivariate analysis assessed the effect of tumor size, pathology, and post-RFA tissue characteristics on LPFS and OS. Post-RFA tissue examination classified 55 of the 68 tumors as completely ablated with coagulation necrosis, with cells positive for caspase-3 and negative for Ki-67 (CN). Thirteen had viable Ki-67-positive tumor cells. Mean liver tumor size was larger in the viable (V) group versus the CN group (3.4 vs. 2.5 cm, respectively; P = .017). For the V and CN groups, respectively, local tumor progression occurred in 12 (92 %) of 13 and 23 (42 %) of 55 specimens. One, 3-, and 5-year LPFS was 8 %, 8 %, and 8 %, and 79 %, 47 %, and 47 % (P <.001) for the V and CN groups, respectively. During a 63-month median follow-up, 92 % of patients in the V group and 58 % in the CN group died, resulting in 1-, 3-, and 5-year OS of 92 %, 25 %, and 8 % vs. 92 %, 59 %, and 33 % (P = .032), respectively. Ki-67-positive tumor cells on the electrode after liver tumor RFA is an independent predictor of LPFS and OS. Size, initially thought to be an independent risk factor for local tumor progression in tumors 3–5 cm, does not hold its significance at long follow-up.
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影响因子：
0.9
作者：
Pulvirenti, A;Garbagnati, F;Mazzaferro, V
通讯作者：
Mazzaferro, V
影响因子：
19.7
作者：
Goldberg, SN;Grassi, CJ;Silverman, SG
通讯作者：
Silverman, SG
影响因子：
45.3
作者：
Garrity, MM;Burgart, LJ;Witzig, TE
通讯作者：
Witzig, TE
影响因子：
19.7
作者：
Livraghi, T;Solbiati, L;Goldberg, SN
通讯作者：
Goldberg, SN
影响因子：
3.7
作者：
Snoeren, Nikol;Huiskens, Joost;van Gulik, Thomas M.
通讯作者：
van Gulik, Thomas M.