The role of mechanical forces in tumor growth and therapy.
The role of mechanical forces in tumor growth and therapy.
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DOI：
10.1146/annurev-bioeng-071813-105259
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发表时间：
2014-07-11
影响因子：
9.7
通讯作者：
Stylianopoulos T
中科院分区：
文献类型：
--
作者：
Jain RK;Martin JD;Stylianopoulos T
肿瘤在生长和进展过程中产生物理力。这些物理力能够压缩血管和淋巴管，降低灌注率并产生缺氧。当直接作用于癌细胞时，它们可以增加其侵袭和转移的潜力。肿瘤血管在滋养肿瘤的同时，通常是泄漏和曲折的，这进一步减少了灌注。低灌注和缺氧有助于免疫逃避，促进恶性进展和转移，并降低许多治疗（包括放射）的疗效。同时，血管渗漏与血管压迫一起导致组织间液压力均匀升高，这阻碍了血液传播治疗剂的递送，降低了化学疗法和纳米疗法的功效。此外，由流动的血液和间质液施加的剪切应力调节癌症和各种宿主细胞的行为。驯服这些物理力量可以改善许多癌症的治疗效果。
Tumors generate physical forces during growth and progression. These physical forces are able to compress blood and lymphatic vessels, reducing perfusion rates and creating hypoxia. When exerted directly on cancer cells, they can increase their invasive and metastatic potential. Tumor vessels - while nourishing the tumor - are usually leaky and tortuous, which further decreases perfusion. Hypo-perfusion and hypoxia contribute to immune-evasion, promote malignant progression and metastasis, and reduce the efficacy of a number of therapies, including radiation. In parallel, vessel leakiness together with vessel compression cause a uniformly elevated interstitial fluid pressure that hinders delivery of blood-borne therapeutic agents, lowering the efficacy of chemo- and nano-therapies. In addition, shear stresses exerted by flowing blood and interstitial fluid modulate the behavior of cancer and a variety of host cells. Taming these physical forces can improve therapeutic outcomes in many cancers.
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影响因子：
3.7
作者：
Cheng G;Tse J;Jain RK;Munn LL
通讯作者：
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影响因子：
2
作者：
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影响因子：
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Jain, Rakesh K.
DOI：
10.1073/pnas.86.14.5385
发表时间：
1989-07-01
影响因子：
11.1
作者：
CHARY, SR;JAIN, RK
通讯作者：
JAIN, RK
DOI：
10.1016/s0020-7225(02)00014-9
发表时间：
2002-07-01
影响因子：
6.6
作者：
Ambrosi, D;Mollica, F
通讯作者：
Mollica, F