Early life protein restriction alters dopamine circuitry.
Early life protein restriction alters dopamine circuitry.
复制标题
DOI：
10.1016/j.neuroscience.2010.04.010
复制
发表时间：
2010-06-30
期刊：
影响因子：
3.3
通讯作者：
Reyes, T. M.
中科院分区：
文献类型：
--
作者：
Vucetic, Z.;Totoki, K.;Schoch, H.;Whitaker, K. W.;Hill-Smith, T.;Lucki, I.;Reyes, T. M.
Adverse prenatal environment, such as intrauterine growth retardation (IUGR), increases the risk for negative neurobehavioral outcomes. IUGR, affecting approximately 10% of all US infants, is a known risk factor for ADHD, schizophrenia spectrum disorders and addiction. Mouse dams were fed a protein deficient (8.5% protein) or isocaloric control (18% protein) diet through pregnancy and lactation (a well validated rodent model of IUGR). Dopamine-related gene expression, dopamine content and behavior were examined in adult offspring. IUGR offspring have 6–8 fold over-expression of dopamine (DA)-related genes (tyrosine hydroxylase (TH) and dopamine transporter) in brain regions related to reward processing (ventral tegmental area (VTA), nucleus accumbens, prefrontal cortex (PFC)) and homeostatic control (hypothalamus), as well as increased number of TH-ir neurons in the VTA and increased dopamine in the PFC. Cyclin-dependent kinase inhibitor 1C (Cdkn1c) is critical for dopaminergic neuron development. Methylation of the promoter region of Cdkn1c was decreased by half and there was a resultant 2–7 fold increase in Cdkn1c mRNA expression across brain regions. IUGR animals demonstrated alterations in dopamine-dependent behaviors, including altered reward-processing, hyperactivity and exaggerated locomotor response to cocaine. These data describe significant dopamine-related molecular and behavioral abnormalities in a mouse model of IUGR. This animal model, with both face validity (behavior) and construct validity (link to IUGR and dopamine dysfunction) may prove useful in identifying underlying mechanisms linking IUGR and adverse neurobehavioral outcomes such as ADHD.
登录
查看更多内容
DOI：
10.1152/ajpregu.90497.2008
发表时间：
2009-08-01
影响因子：
2.8
作者：
Bol, V. V.;Delattre, A-I.;Remacle, C.
通讯作者：
Remacle, C.
影响因子：
17.7
作者：
Brown, AS;van Os, J;Susser, ES
通讯作者：
Susser, ES
影响因子：
3
作者：
Clancy, Barbara;Kersh, Brandon;Finlay, Barbara L.
通讯作者：
Finlay, Barbara L.
影响因子：
4.8
作者：
Itoh, Yasuhiro;Masuyama, Norihisa;Gotoh, Yukiko
通讯作者：
Gotoh, Yukiko
影响因子：
2.7
作者：
Bekris, S;Antoniou, K;Papadopoulou-Daifoti, Z
通讯作者：
Papadopoulou-Daifoti, Z