Two-stage meta-analysis of survival data from individual participants using percentile ratios.

Two-stage meta-analysis of survival data from individual participants using percentile ratios.
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DOI:
10.1002/sim.5516
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发表时间:
2012-12-30
影响因子:
2
通讯作者:
Higgins, Julian P. T.
Higgins, Julian P. T.
中科院分区:
医学3区
文献类型:
--
作者:
Barrett, Jessica K.;Farewell, Vern T.;Siannis, Fotios;Tierney, Jayne;Higgins, Julian P. T.

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生存结局的个体参与者数据荟萃分析方法通常侧重于风险比作为治疗效果的衡量标准。最近,Siannis等人(2010,Statistics in Medicine 29:3030-3045)提出使用百分位数比率作为风险比率的替代。我们描述了一种新的两阶段方法的百分位数比值的荟萃分析,避免了在研究水平的分布假设。版权所有© 2012约翰威利父子有限公司.
Methods for individual participant data meta-analysis of survival outcomes commonly focus on the hazard ratio as a measure of treatment effect. Recently, Siannis et al. (2010, Statistics in Medicine 29:3030–3045) proposed the use of percentile ratios as an alternative to hazard ratios. We describe a novel two-stage method for the meta-analysis of percentile ratios that avoids distributional assumptions at the study level. Copyright © 2012 John Wiley & Sons, Ltd.
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