Measuring functional connectivity with wearable MEG.
Measuring functional connectivity with wearable MEG.
复制标题
使用可穿戴MEG测量功能连接。
DOI：
10.1016/j.neuroimage.2021.117815
复制
发表时间：
2021-04-15
期刊：
影响因子：
5.7
通讯作者：
Brookes MJ
中科院分区：
文献类型：
--
作者：
Boto E;Hill RM;Rea M;Holmes N;Seedat ZA;Leggett J;Shah V;Osborne J;Bowtell R;Brookes MJ
光泵磁力计 (OPM) 为脑磁图 (MEG) 的逐步变革提供了潜力，使可穿戴系统能够提供更高的数据质量、适应任何受试者群体、允许在运动过程中捕获数据并可能降低成本。然而，OPM-MEG 是一项新兴技术，为了发挥其潜力，必须证明它可以促进关键的神经科学测量，例如大脑网络的表征。网络及其背后的连接性已成为神经科学研究的核心领域，其重要性通过其对大脑疾病的破坏的许多证据得到强调。因此，使用 OPM-MEG 进行网络测量演示将是向前迈出的重要一步。在这里，我们的目的是展示可穿戴 50 通道 OPM-MEG 系统能够表征电生理连接组。为此，我们使用 OPM-MEG 和最先进的 275 通道低温 MEG 设备测量了静息状态和视觉运动任务期间的连接性。我们的结果表明，OPM 和低温系统的静息态连接组矩阵表现出高度相似性，相关值 > 70%。此外，在任务数据中，在低温和 OPM-MEG 数据中观察到个体之间连接性的类似差异（多次扫描），再次证明了 OPM-MEG 设备的保真度。这是使用 OPM-MEG 测量网络连接的首次演示，结果进一步证明了 OPM 将最终取代用于 MEG 测量的低温传感器的论点。
Optically-pumped magnetometers (OPMs) offer the potential for a step change in magnetoencephalography (MEG) enabling wearable systems that provide improved data quality, accommodate any subject group, allow data capture during movement and potentially reduce cost. However, OPM-MEG is a nascent technology and, to realise its potential, it must be shown to facilitate key neuroscientific measurements, such as the characterisation of brain networks. Networks, and the connectivities that underlie them, have become a core area of neuroscientific investigation, and their importance is underscored by many demonstrations of their disruption in brain disorders. Consequently, a demonstration of network measurements using OPM-MEG would be a significant step forward. Here, we aimed to show that a wearable 50-channel OPM-MEG system enables characterisation of the electrophysiological connectome. To this end, we measured connectivity in the resting state and during a visuo-motor task, using both OPM-MEG and a state-of-the-art 275-channel cryogenic MEG device. Our results show that resting-state connectome matrices from OPM and cryogenic systems exhibit a high degree of similarity, with correlation values >70%. In addition, in task data, similar differences in connectivity between individuals (scanned multiple times) were observed in cryogenic and OPM-MEG data, again demonstrating the fidelity of the OPM-MEG device. This is the first demonstration of network connectivity measured using OPM-MEG, and results add weight to the argument that OPMs will ultimately supersede cryogenic sensors for MEG measurement.
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影响因子：
5.7
作者：
Barry, Daniel N.;Tierney, Tim M.;Maguire, Eleanor A.
通讯作者：
Maguire, Eleanor A.
在头皮安装的磁刻摄影术中用于无效背景磁场的双平面线圈系统。
影响因子：
5.7
作者：
Holmes N;Leggett J;Boto E;Roberts G;Hill RM;Tierney TM;Shah V;Barnes GR;Brookes MJ;Bowtell R
通讯作者：
Bowtell R
影响因子：
3.7
作者：
Boto E;Bowtell R;Krüger P;Fromhold TM;Morris PG;Meyer SS;Barnes GR;Brookes MJ
通讯作者：
Brookes MJ
DOI：
10.1098/rstb.2005.1634
发表时间：
2005-05-29
影响因子：
6.3
作者：
Beckmann, CF;DeLuca, M;Smith, SM
通讯作者：
Smith, SM
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y