Frontal Lobe Function Correlates with One-Year Incidence of Urinary Incontinence in Elderly with Alzheimer Disease.
Frontal Lobe Function Correlates with One-Year Incidence of Urinary Incontinence in Elderly with Alzheimer Disease.
复制标题
额叶功能与阿尔茨海默病老年人一年尿失禁的发病率相关。
DOI：
10.3233/jad-160923
复制
发表时间：
2017
期刊：
影响因子：
--
通讯作者：
T. Sakurai
中科院分区：
文献类型：
--
作者：
T. Sugimoto;Masaki Yoshida;R. Ono;Shunsuke Murata;Naoki Saji;S. Niida;K. Toba;T. Sakurai
背景
阿尔茨海默病（AD）患者经常出现尿失禁（UI）。虽然以前的作品突出了额叶相关功能和UI之间的联系，因果关系尚不清楚。
对象
阐明AD患者1年时额叶功能与UI发生率之间的纵向相关性。
方法
受试者为215名大陆AD患者，他们在2011年3月至2014年12月期间参加了日本国立老年医学和老年学中心的记忆诊所。是否存在UI由痴呆行为障碍量表子量表操作分配，该量表由患者的照顾者完成。使用额叶评估组合（FAB）评估额叶功能。评估了其他混杂因素，包括人口统计学数据、认知状态、活力、情绪、体能和药物使用（胆碱酯酶抑制剂、钙通道阻滞剂[CCB]、利尿剂、α受体阻滞剂和抗胆碱能药物）。
结果
随访1年（平均377.4±83.7天），UI发生率为12.1%（n = 26）。 UI患者在基线时的FAB性能显著较低（无UI vs UI = 9.3±2.8 vs 7.8±2.7）。 在多因素分析中，逐步Logistic回归分析显示FAB（OR = 0.79，95%置信区间[CI]= 0.66-0.94）和CCB的使用（OR = 2.72，95% CI = 1.09-6.77）与1年时的UI显著相关。
结论
研究结果表明，额叶功能障碍是AD患者UI的预测因子。
BACKGROUND
Urinary incontinence (UI) is frequently observed in patients with Alzheimer's disease (AD). Although previous works highlight the association between frontal lobe-related function and UI, causal relationship is unclear.
OBJECTS
To clarify the longitudinal association between frontal lobe function and the incidence of UI at 1 year in patients with AD.
METHODS
The subjects were 215 continent AD patients who attended the Memory Clinic of the National Center for Geriatrics and Gerontology of Japan during the period from March 2011 to December 2014. The absence or presence of UI was operationally assigned by the dementia behavior disturbance scale subscale, which was completed by the patients' caregivers. Frontal lobe function was assessed using the Frontal Assessment Battery (FAB). Other confounding factors including demographic data, cognitive status, vitality, mood, physical performance, and use of medication (cholinesterase inhibitors, calcium channel blockers [CCBs], diuretics, alpha blockers and anticholinergic drugs) were assessed.
RESULTS
During 1-year follow up (mean: 377.4±83.7 days), the incidence of UI was 12.1% (n = 26). Patients with UI had significantly lower FAB performance at baseline (no UI versus UI = 9.3±2.8 versus 7.8±2.7). In multivariate analysis, stepwise logistic regression analysis demonstrated that FAB (odds ratio [OR] = 0.79, 95% confidence interval [CI] = 0.66-0.94) and the use of CCB (OR = 2.72, 95% CI = 1.09-6.77) were significantly associated with UI at 1 year.
CONCLUSION
The results of study indicate that frontal lobe dysfunction is predictor for UI in patients with AD.
DOI：
10.1016/j.juro.2010.05.095
发表时间：
2010-10
期刊：
The Journal of urology
影响因子：
--
作者：
Thom DH;Brown JS;Schembri M;Ragins AI;Subak LL;Van Den Eeden SK
通讯作者：
Van Den Eeden SK