Convergent evidence for the molecular basis of musical traits.
Convergent evidence for the molecular basis of musical traits.
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DOI：
10.1038/srep39707
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发表时间：
2016-12-22
影响因子：
4.6
通讯作者：
Kanduri C
中科院分区：
文献类型：
--
作者：
Oikkonen J;Onkamo P;Järvelä I;Kanduri C
为了获得音乐能力和音乐影响的分子基础的综合证据，我们整合了来自105项已发表的研究的基因水平数据，这些研究涉及多个物种，包括人类、鸣禽和其他几种动物，并使用收敛证据方法来优先考虑顶级候选基因。已知几个已确定的顶级候选基因，如EGR 1，FOS，ARC，BDNF和DUSP 1，是对大脑中的感觉和运动刺激做出反应的活动依赖性立即早期基因。其他几个热门候选基因，如MAPK 10，SNCA，ARHGAP 24，TET 2，UBE 2D 3，FAM 13 A和NUDT 9位于染色体4 q21-q24上，位于人类音乐能力的候选基因组区域。功能注释分析显示，参与认知、学习、记忆、神经元兴奋和凋亡、长时程增强和CDK 5信号通路等功能的基因富集。有趣的是，所有这些生物功能都是学习和记忆的基本过程，也是音乐能力的基础，包括识别和产生声音。总之，我们的研究优先考虑了与音乐特质相关的候选基因。
To obtain aggregate evidence for the molecular basis of musical abilities and the effects of music, we integrated gene-level data from 105 published studies across multiple species including humans, songbirds and several other animals and used a convergent evidence method to prioritize the top candidate genes. Several of the identified top candidate genes like EGR1, FOS, ARC, BDNF and DUSP1 are known to be activity-dependent immediate early genes that respond to sensory and motor stimuli in the brain. Several other top candidate genes like MAPK10, SNCA, ARHGAP24, TET2, UBE2D3, FAM13A and NUDT9 are located on chromosome 4q21-q24, on the candidate genomic region for music abilities in humans. Functional annotation analyses showed the enrichment of genes involved in functions like cognition, learning, memory, neuronal excitation and apoptosis, long-term potentiation and CDK5 signaling pathway. Interestingly, all these biological functions are known to be essential processes underlying learning and memory that are also fundamental for musical abilities including recognition and production of sound. In summary, our study prioritized top candidate genes related to musical traits.
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影响因子：
2.5
作者：
Jarvis, Erich D.;Yu, Jing;Rivas, Miriam V.;Horita, Haruhito;Feenders, Gesa;Whitney, Osceola;Jarvis, Syrus C.;Jarvis, Electra R.;Kubikova, Lubica;Puck, Ana E. P.;Siang-Bakshi, Connie;Martin, Suzanne;McElroy, Michael;Hara, Erina;Howard, Jason;Pfenning, Andreas;Mouritsen, Henrik;Chen, Chun-Chun;Wada, Kazuhiro
通讯作者：
Wada, Kazuhiro
影响因子：
9.2
作者：
Groszer, Matthias;Keays, David A.;Deacon, Robert M. J.;de Bono, Joseph P.;Prasad-Mulcare, Shweta;Gaub, Simone;Baum, Muriel G.;French, Catherine A.;Nicod, Jrme;Coventry, Julie A.;Enard, Wolfgang;Fray, Martin;Brown, Steve D. M.;Nolan, Patrick M.;Paeaebo, Svante;Channon, Keith M.;Costa, Rui M.;Eilers, Jens;Ehret, Guenter;Nicholas, J.;Rawlins, P.;Fisher, Simon E.
通讯作者：
Fisher, Simon E.
影响因子：
25
作者：
London, Sarah E.;Clayton, David F.
通讯作者：
Clayton, David F.
DOI：
10.1073/pnas.1200655109
发表时间：
2012-10-16
影响因子：
11.1
作者：
Drnevich, Jenny;Replogle, Kirstin L.;Clayton, David F.
通讯作者：
Clayton, David F.
影响因子：
4
作者：
Le-Niculescu, Helen;Patel, Sagar D.;Niculescu, Alexander B.
通讯作者：
Niculescu, Alexander B.