Increased risk of cancer among azoospermic men.
Increased risk of cancer among azoospermic men.
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DOI：
10.1016/j.fertnstert.2013.05.022
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发表时间：
2013-09
影响因子：
6.7
通讯作者：
Lipshultz, Larry I.
中科院分区：
文献类型：
--
作者：
Eisenberg, Michael L.;Betts, Paul;Herder, Danielle;Lamb, Dolores J.;Lipshultz, Larry I.
确定无精子症男性在不孕症评估后的几年内患癌症的风险是否增加。队列研究美国男科诊所从1989年到2009年，在德克萨斯州的一家男科诊所对2,238名有完整记录的男性进行了不孕症评估。没有癌症发病率是通过与德克萨斯州癌症登记处的联系确定的。共有451名男性患有无精子症，1，787名男性没有无精子症，不育评估的平均年龄为35.7岁。与一般人群相比，不育男性患癌症的风险更高，观察到29例病例，而预期为16.7例（SIR 1.7，95% CI 1.2-2.5）。当按无精子症状态分层时，无精子症男性患癌症的风险升高（SIR 2.9，95% CI 1.4-5.4）。无精子症的不育男性有癌症发生率较高的趋势（SIR 1.4，95% CI 0.9-2.2）。考克斯回归模型显示，无精子症男性的癌症风险是非无精子症男性的2.2倍（HR 2.2，95% CI 1.0-4.8）。男性无精子症有一个随后发展为癌症的风险增加，这表明无精子症和癌症发展之间可能有共同的病因。无精子症男性在生殖努力结束后的额外随访可能是必要的。
To determine if men with azoospermia are at an elevated risk of developing cancer in the years following an infertility evaluation. Cohort Study United States andrology clinic 2,238 men with complete records were evaluated for infertility at a single andrology clinic in Texas from 1989 to 2009. None Cancer incidence was determined by linkage to the Texas Cancer Registry. In all, 451 men had azoospermia and 1,787 were not azoospermic with a mean age at infertility evaluation of 35.7 years. Compared to the general population, infertile men had a higher risk of cancer with 29 cases observed compared with 16.7 expected (SIR 1.7, 95% CI 1.2–2.5). When stratifying by azoospermia status, azoospermic men had an elevated risk of cancer (SIR 2.9, 95% CI 1.4–5.4). Infertile men without azoospermia had a trend towards a higher rate of cancer (SIR 1.4, 95% CI 0.9–2.2). The Cox regression model revealed that azoospermic men had 2.2-fold higher cancer risk compared to not azoospermic men (HR 2.2, 95% CI 1.0–4.8). Men with azoospermia have an increased risk of subsequently developing cancer, suggesting a possible common etiology between azoospermia and cancer development. Additional follow-up of azoospermic men after reproductive efforts end may be warranted.
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