The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial.
The effect of vitamin D supplementation on knee osteoarthritis, the VIDEO study: a randomised controlled trial.
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DOI：
10.1016/j.joca.2016.05.020
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发表时间：
2016-11
影响因子：
7
通讯作者：
Keen, R.
中科院分区：
文献类型：
--
作者：
Arden, N. K.;Cro, S.;Sheard, S.;Dore, C. J.;Bara, A.;Tebbs, S. A.;Hunter, D. J.;James, S.;Cooper, C.;O'Neill, T. W.;Macgregor, A.;Birrell, F.;Keen, R.
膝骨关节炎 (OA) 是一个常见问题，随着老龄化人口的患病率不断增加。没有获得许可的治疗方法可以改变疾病进展。流行病学数据表明，低血清 25-羟基维生素 D3 (25-OH-D3) 水平与膝 OA 的放射学进展相关。本研究旨在评估补充维生素 D 是否可以预防膝关节 OA 的放射学进展。一项为期 3 年、双盲、随机、安慰剂对照试验，对 474 名 50 岁以上膝骨关节炎患者进行了比较，每天服用 800 IU 胆钙化醇与安慰剂。主要结果是三年内内侧间室关节间隙狭窄（JSN）的发生率。次要结局包括 WOMAC 疼痛、功能和僵硬。补充维生素 D 可使 25-OH-D3 从平均 20·7 (8·9) μg/L 增加至 30·4 (7·7) μg/L，而安慰剂组为 20·7 (8·1) μg/L 和 20·3 (8·1) μg/L。相对于对照组，治疗组中观察到 JSN 发生率非显着下降 0.08 mm/年（95% CI -0·14 至 0·29，p=0.49）。基线维生素 D 水平与治疗效果之间没有发现显着的相互作用。任何次要结果指标均无显着差异。与安慰剂相比，补充维生素 D 的剂量足以在一年内将血清维生素 D3 水平提高近 10 μg/L，但不会减慢 JSN 的发生率，也不会在三年内减少疼痛、僵硬或功能丧失。
Knee osteoarthritis (OA) is a common problem with increasing prevalence in an ageing population. There are no licensed treatments to modify disease progression. Epidemiological data suggest that low serum 25-hydroxyvitamin D3 (25-OH-D3) levels are associated with radiological progression of knee OA. This study aimed to assess whether vitamin D supplementation can prevent the radiological progression of knee OA. A 3 year, double-blind, randomised, placebo-controlled trial 474 patients aged over 50 with knee OA comparing 800 IU cholecalciferol daily with placebo. The primary outcome was rate of joint space narrowing (JSN) in the medial compartment over three years. Secondary outcomes included WOMAC pain, function and stiffness. Vitamin D supplementation increased 25-OH-D3 from an average of 20·7 (8·9) μg/L to 30·4 (7·7) μg/L, compared to 20·7 (8·1) μg/L and 20·3 (8·1) μg/L in the placebo group. A non-significant decrease of 0.08 mm/year (95% CI -0·14 to 0·29, p=0.49) in the rate of JSN was observed in the treatment group relative to the control. No significant interactions were found between baseline vitamin D levels and treatment effects. There were no significant differences in any of the secondary outcome measures. Vitamin D supplementation at a dose sufficient to elevate serum vitamin D3 levels by almost 10 μg/L in one year, when compared with placebo, does not slow the rate of JSN or lead to reduced pain, stiffness or functional loss over a three year period.
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升压对关节结构和膝关节骨关节炎症状的影响：轻快的随机，对照试验的结果[ISRCTN01928173]。
影响因子：
4.9
作者：
Spector, Tim D;Conaghan, Philip G;Buckland-Wright, J Christopher;Garnero, Patrick;Cline, Gary A;Beary, John F;Valent, David J;Meyer, Joan M
通讯作者：
Meyer, Joan M
影响因子：
27.4
作者：
Bruyere, O;Richy, F;Reginster, JY
通讯作者：
Reginster, JY
影响因子：
2.1
作者：
Konstari, S.;Paananen, M.;Karppinen, J.
通讯作者：
Karppinen, J.
影响因子：
39.2
作者：
McAlindon, TE;Felson, DT;Jacques, P
通讯作者：
Jacques, P
影响因子：
5.5
作者：
Duddy, J;Kirwan, JR;Volkov, S
通讯作者：
Volkov, S