Lowered entrainment function in the suprachiasmatic nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) rats.
Lowered entrainment function in the suprachiasmatic nucleus of Otsuka Long Evans Tokushima Fatty (OLETF) rats.
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降低 Otsuka Long Evans Tokushima Fatty (OLETF) 大鼠视交叉上核的夹带功能。
DOI：
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发表时间：
1999
期刊：
影响因子：
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通讯作者：
A. Funakoshi
中科院分区：
文献类型：
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作者：
T. Shimazoe;M. Maetani;S. Nakamura;S. Yamanouchi;S. Watanabe;K. Miyasaka;A. Kono;A. Funakoshi
本文观察了非糖尿病大冢长埃文斯德岛肥胖（OLETF）幼鼠视交叉上核（SCN）的卷吸功能。OLETF大鼠比对照Long Evans德岛大冢（LETO）大鼠显著需要更多的天数重新夹带到一个新的光-暗周期。我们还评估了暗光照射诱导的SCN中的Fos表达。与LETO大鼠相比，5- 13周龄OLETF大鼠的Fos免疫反应细胞数量显著减少。此外，研究了谷氨酸对OLETF大鼠SCN神经元活动的影响。在年轻的非糖尿病OLETF大鼠中，1 μ M谷氨酸诱导的SCN神经元放电节律的相位延迟显著小于LETO大鼠。这些结果表明，在OLETF大鼠糖尿病发病前，夹带功能降低。
The entrainment function in the suprachiasmatic nucleus (SCN) of young non-diabetic Otsuka Long Evans Tokushima Fatty (OLETF) rats was studied. OLETF rats significantly needed more days for re-entrainment to a new light-dark cycle than control Long Evans Tokushima Otsuka (LETO) rats. We also assessed Fos expression in the SCN induced by dim light exposure. The number of Fos-immunoreactive cells was significantly decreased in 5- to 13-week-old OLETF rats compared with LETO rats. Moreover, the effect of glutamate on neuronal activity in the SCN of OLETF rats were investigated. In young non-diabetic OLETF rats, the phase delay in the SCN neuronal firing rhythm induced by 1 microM glutamate was significantly less than that in LETO rats. These results suggested that the entrainment function is reduced in OLETF rats before the onset of diabetes.
糖尿病大鼠皮质酮的昼夜节律。
影响因子：
6.1
作者：
Oster,MH;Castonguay,TW;Keen,CL;Stern,JS
通讯作者：
Stern,JS