Circadian rhythm of corticosterone in diabetic rats.
Circadian rhythm of corticosterone in diabetic rats.
复制标题
糖尿病大鼠皮质酮的昼夜节律。
DOI：
10.1016/0024-3205(88)90536-x
复制
发表时间：
1988
期刊：
影响因子：
6.1
通讯作者：
Stern,JS
中科院分区：
文献类型：
--
作者：
Oster,MH;Castonguay,TW;Keen,CL;Stern,JS
我们认为糖尿病大鼠皮质酮的昼夜节律与非糖尿病对照大鼠不同。为了检验这一假设，20只雄性Sprague-Dawley大鼠自由采食储备饲料，并单独饲养在光照和温度受控的房间中。通过两次皮下注射链脲佐菌素使10只大鼠患糖尿病。10只未注射的大鼠作为对照。在诱导糖尿病后13天，每4 h采集尾血样品，持续24 h。血浆皮质酮水平显着高于糖尿病大鼠比对照组大鼠在3个时间点在光周期，但是，浓度在黑暗周期中是相似的。我们推测，糖尿病可能会导致类固醇反馈机制的改变，下丘脑和/或垂体，导致异常的昼夜节律的血浆皮质酮。
We proposed that the circadian rhythm of corticosterone in diabetic rats would have a different pattern than that in non-diabetic control rats. To test this hypothesis, 20 male Sprague-Dawley rats were given ad libitum access to a stock diet and housed individually in a light and temperature controlled room. Ten rats were made diabetic by two subcutaneous injections of streptozotocin. Ten rats which were not injected served as controls. Thirteen days after induction of the diabetes, tail blood samples were taken every 4 h for 24 h. Plasma corticosterone levels were significantly higher in diabetic rats than in control rats at 3 time points during the light cycle; however, concentrations were similar during the dark cycle. We speculate that diabetes may cause alterations in the steroid feedback mechanism to the hypothalamus and/or pituitary, resulting in an abnormal circadian rhythm of plasma corticosterone.
登录
查看更多内容
链脲佐菌素对糖尿病雄性大鼠肾上腺功能的影响
DOI：
--
发表时间：
1976
期刊：
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
影响因子：
--
作者：
A. D. Nicola;O. Fridman;E. Castillo;V. Varga;M. Kawada;L. Aguilera;A. Ortuzar;D. Videla;Dr. L. Vargas;V. G. Foglia
通讯作者：
V. G. Foglia
接受治疗的糖尿病儿童血清中的皮质激素。
影响因子：
8
作者：
R. Klein;F. Weigand;M. Iunes;L. Greenman
通讯作者：
L. Greenman
链脲佐菌素诱导的糖尿病小鼠的激动行为模式
影响因子：
2.9
作者：
W. P. Meehan;L. Leedom;Takahisa Nagayama;A. Zeidler
通讯作者：
A. Zeidler
糖尿病患者的下丘脑-垂体-肾上腺皮质活动。
影响因子：
--
作者：
Cameron,OG;Kronfol,Z;Greden,JF;Carroll,BJ
通讯作者：
Carroll,BJ
二十四小时皮质醇曲线显示糖尿病儿童夜间皮质醇升高过度
影响因子：
16.2
作者：
T. Lebinger;Paul V. Saenger;D. Fukushima;J. Kream;R. Wu;J. Finkelstein
通讯作者：
J. Finkelstein