Trends in long-term opioid therapy for chronic non-cancer pain.
Trends in long-term opioid therapy for chronic non-cancer pain.
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长期阿片类药物治疗慢性非癌性疼痛的趋势。
DOI：
10.1002/pds.1833
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发表时间：
2009-12
影响因子：
2.6
通讯作者：
Weisner, Constance
中科院分区：
文献类型：
--
作者：
Boudreau, Denise;Von Korff, Michael;Rutter, Carolyn M.;Saunders, Kathleen;Ray, G. Thomas;Sullivan, Mark D.;Campbell, Cynthia I.;Merrill, Joseph O.;Silverberg, Michael J.;Banta-Green, Caleb;Weisner, Constance
报告长期使用阿片类药物治疗非癌症疼痛的趋势和特点。Conort(研究阿片类药物风险和趋势的联盟)包括两个健康计划的成年参与者，服务于超过1%的美国人口。使用自动化数据，我们构建了1997至2005年间阿片类药物的使用情况。我们估计了从每年开始的阿片类药物使用事件的年龄-性别标准化比率(事件)和每年正在进行的阿片类药物使用事件的标准化比率(流行)，以及9年期间年化比率的变化百分比(PCA)。长期发作被定义为90天内120天以上的供应或在给定年份内10+阿片类药物处方。在研究期间，事件长期使用量在团体健康(GH)(6.0%PCA)从8.5/1000增加到12.1/1000，在北加州Kaiser Permanente(KPNC)(5.5%)从6.3/1000增加到8.6/1000。GH(8.5%PCA)和KPNC(8.1%PCA)的普遍长期使用量从23.9‰翻了一番至46.8‰，KPNC从21.5‰增至39.2‰。非附表二阿片类药物是长期接受阿片类药物治疗的患者中最常用的阿片类药物，特别是在KPNC。在这两个健康计划中，附表二阿片类药物的长期使用也大幅增加。在2005年流行的长期使用者中，GH的28.6%和KPNC的30.2%也经常使用镇静催眠药。非癌性疼痛的长期阿片类药物治疗越来越普遍，但与这种治疗相关的好处和风险还没有得到充分的了解。同时使用阿片类药物和镇静催眠药出人意料地普遍，值得进一步研究。
To report trends and characteristics of long-term opioid use for non-cancer pain. CONSORT (CONsortium to Study Opioid Risks and Trends) includes adult enrollees of two health plans serving over one-percent of the US population. Using automated data, we constructed episodes of opioid use between 1997 and 2005. We estimated age-sex standardized rates of opioid use episodes beginning in each year (incident) and on-going in each year (prevalent), and the percent change in rates annualized (PCA) over the 9 year period. Long-term episodes were defined as > 90 days with 120+ days supply or 10+ opioid prescriptions in a given year. Over the study period, incident long-term use increased from 8.5 to 12.1 per 1,000 at Group Health (GH) (6.0% PCA), and 6.3 to 8.6 per 1,000 at Kaiser Permanente of Northern California (KPNC) (5.5% PCA). Prevalent long-term use doubled from 23.9 to 46.8 per 1,000 at GH (8.5% PCA), and 21.5 to 39.2 per 1,000 at KPNC (8.1% PCA). Non-Schedule II opioids were the most commonly used opioid among patients engaged in long-term opioid therapy, particularly at KPNC. Long-term use of Schedule II opioids also increased substantially at both health plans. Among prevalent long-term users in 2005, 28.6% at GH and 30.2% at KPNC were also regular users of sedative hypnotics. Long-term opioid therapy for non-cancer pain is increasingly prevalent, but the benefits and risks associated with such therapy are inadequately understood. Concurrent use of opioids and sedative-hypnotics was unexpectedly common and deserves further study.
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影响因子：
7.4
作者：
Caudill-Slosberg, MA;Schwartz, LM;Woloshin, S
通讯作者：
Woloshin, S
影响因子：
3.1
作者：
Inciardi, James A.;Surratt, Hilary L.;Cicero, Theodore J.
通讯作者：
Cicero, Theodore J.
影响因子：
39.2
作者：
MARKS, RM;SACHAR, EJ
通讯作者：
SACHAR, EJ
影响因子：
120.7
作者：
Joranson, DE;Ryan, KM;Dahl, JL
通讯作者：
Dahl, JL
影响因子：
--
作者：
Moore, Thomas J.;Cohen, Michael R.;Furberg, Curt D.
通讯作者：
Furberg, Curt D.