High-throughput determination of RNA structures.
High-throughput determination of RNA structures.
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DOI:
10.1038/s41576-018-0034-x
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发表时间:
2018-10
期刊:
影响因子:
--
通讯作者:
Lucks JB
中科院分区:
文献类型:
--
作者:
Strobel EJ;Yu AM;Lucks JB
The broad roles of RNA in performing and regulating fundamental life processes are being uncovered at a rapid pace. This has sparked profound questions about how RNA function is enacted through RNA structures that orchestrate processes in the complex cellular environment. These questions are being answered with technologies that use massively parallel sequencing to interrogate RNA structure at unprecedented throughput. In this article, we place the growing number of these technologies on a common conceptual framework, review their technical underpinnings, discuss the meaning and use of their data, and highlight their application to new areas of RNA biology.
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