Reconfiguration of a Multi-oscillator Network by Light in the Drosophila Circadian Clock.
Reconfiguration of a Multi-oscillator Network by Light in the Drosophila Circadian Clock.
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DOI：
10.1016/j.cub.2018.04.064
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发表时间：
2018-07-09
期刊：
影响因子：
--
通讯作者：
Rouyer F
中科院分区：
文献类型：
--
作者：
Chatterjee A;Lamaze A;De J;Mena W;Chélot E;Martin B;Hardin P;Kadener S;Emery P;Rouyer F
驱动运动活动昼夜节律的大脑时钟依赖于多振荡器神经元网络。除了使时钟与昼夜周期同步之外，光还可以重新格式化时钟驱动的日常活动模式。照明条件的变化如何改变不同振荡器的贡献以重塑日常活动模式仍然很大程度上未知。我们在果蝇中的数据表明，光通过两种不同的模式重新调整振荡器之间的相互作用。我们表明，早上的 s-LNv > DN1p 电路串联工作，而两个并行的晚上电路由 LNds 和其他 DN1p 贡献。根据光环境，s-LNv 神经元中的主起搏器交换其从属伙伴振荡器（有光时为 LNd，无光时为 DN1p），以始终与最有影响力的相位确定振荡器连接。当光照进一步增加时，光激活 LNd 起搏器通过与 s-LNvs 解耦而变得独立。光耦合的校准是在与时钟无关的网络相互作用上进行的，其中光上调 s-LNv 中 PDF 神经肽的表达，从而抑制 DN1p 晚间振荡器的行为输出。因此，光修改了振荡器间耦合和与时钟无关的输出门控，以实现网络的灵活性。光引起的果蝇大脑昼夜节律网络的变化很可能揭示任何神经元多振荡器系统适应不同环境线索的一般原理。 Chatterjee 等人表明，光改变了果蝇大脑时钟网络中振荡器间的耦合和时钟独立的输出门控。不同振荡器节点之间相互作用的这种动态灵活性（部分由神经肽 PDF 定义）允许硬连线时钟网络平衡稳健性和适应性。
The brain clock that drives circadian rhythms of locomotor activity relies on a multi-oscillator neuronal network. In addition to synchronizing the clock with day-night cycles, light also reformats the clock-driven daily activity pattern. How changes in lighting conditions modify the contribution of the different oscillators to remodel the daily activity pattern remains largely unknown. Our data in Drosophila indicate that light readjusts the interactions between oscillators through two different modes. We show that a morning s-LNv > DN1p circuit works in series whereas two parallel evening circuits are contributed by LNds and other DN1ps. Based on the photic context, the master pacemaker in the s-LNv neurons swaps its enslaved partner-oscillator - LNd in the presence of light or DN1p in the absence of light - to always link up with the most influential phase-determining oscillator. When exposure to light further increases, the light-activated LNd pacemaker becomes independent by decoupling from the s-LNvs. The calibration of coupling by light is layered on a clock-independent network interaction wherein light upregulates the expression of the PDF neuropeptide in the s-LNvs, which inhibits the behavioral output of the DN1p evening oscillator. Thus, light modifies inter-oscillator coupling and clock-independent output-gating to achieve flexibility in the network. It is likely that the light-induced changes in the Drosophila brain circadian network could reveal general principles of adapting to varying environmental cues in any neuronal multi-oscillator system. Chatterjee et al., show that light modifies inter-oscillator coupling and clock-independent output-gating in the Drosophila brain clock network. This dynamic flexibility in the interactions among the different oscillator nodes, in part defined by the neuropeptide PDF, allow the hardwired clock network to balance robustness with adaptability.
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