The antiviral activity of antibodies in vitro and in vivo.
The antiviral activity of antibodies in vitro and in vivo.
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DOI：
10.1016/s0065-2776(01)77018-6
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发表时间：
2001
影响因子：
--
通讯作者：
Burton DR
中科院分区：
文献类型：
--
作者：
Parren PW;Burton DR
本章讨论了抗体的体外和体内抗病毒活性。由于体外实验要容易得多，因此研究人员一直在寻求开发预期可预测体内活性的体外测定。这在疫苗设计和被动抗体施用中可能是重要的。所提出的体外中和机制的范围从需要单个抗体分子与病毒结合的机制到需要基本上完全抗体包被病毒的机制。在体外，抗病毒活性可分为针对病毒体的活性和针对感染细胞的活性。最常考虑的针对病毒粒子的活性是中和，其可以被定义为感染性的丧失，其在抗体分子与病毒颗粒结合时发生，并且在没有任何其他机构参与的情况下发生。在体内，通常在现象上区分两种类型的抗体抗病毒活性。其中之一是抗体在感染前或感染后立即存在时保护免受感染的能力。许多体外病毒的证据表明，抑制游离病毒传播的感染所需的抗体浓度低于抑制细胞间传播的感染所需的抗体浓度。
This chapter discusses in vitro and in vivo antiviral activities of antibody. Since experimentation is far easier in vitro, researchers have been sought to develop in vitro assays that are expected to predict activity in vivo. This could be important in both vaccine design and in passive antibody administration. The proposed mechanisms of in vitro neutralization range from those requiring binding of a single antibody molecule to virus to those requiring substantially complete antibody coating of virus. In vitro, antiviral activity can be separated into activity against virions and activity against infected cells. The activity against virions most often considered is neutralization that can be defined as the loss of infectivity, which ensues when antibody molecule(s) bind to a virus particle, and occurs without the involvement of any other agency. In vivo, it is conventional to distinguish phenomenologically between two types of antibody antiviral activity. One of them is the ability of antibody to protect against infection when it is present before or immediately following infection. Evidence for a number of viruses in vitro indicates that lower antibody concentrations are required to inhibit infection propagated by free virus than are required to inhibit infection propagated by cell-to-cell spread.
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影响因子：
5.4
作者：
BALDRIDGE, JR;BUCHMEIER, MJ
通讯作者：
BUCHMEIER, MJ
DOI：
10.1038/icb.1937.23
发表时间：
1937-01-01
期刊：
Australian Journal of Experimental Biology and Medical Science
影响因子：
--
作者：
Burnet, F. M.;Keogh, E. V.;Lush, Dora.
通讯作者：
Lush, Dora.
影响因子：
56.9
作者：
Burns, JW;SiadatPajouh, M;Greenberg, HB
通讯作者：
Greenberg, HB
影响因子：
64.5
作者：
ARTHOS, J;DEEN, KC;SWEET, RW
通讯作者：
SWEET, RW
影响因子：
5.4
作者：
BLONDEL, B;CRAINIC, R;HORAUD, F
通讯作者：
HORAUD, F