Rhodol Derivatives as Selective Fluorescent Probes for the Detection of Hg(II) Ions and the Bioimaging of Hypochlorous Acid.
Rhodol Derivatives as Selective Fluorescent Probes for the Detection of Hg(II) Ions and the Bioimaging of Hypochlorous Acid.
复制标题
Rhodol 衍生物作为选择性荧光探针用于检测 Hg-II 离子和次氯酸的生物成像
DOI：
10.1002/open.201700154
复制
发表时间：
2018-03
期刊：
影响因子：
2.3
通讯作者：
Wong KM
中科院分区：
文献类型：
--
作者：
Li L;Wang S;Lan H;Gong G;Zhu Y;Tse YC;Wong KM
Two sensors, 1 with a spirolactone group and 2 with a spirolactam group containing a phenyl isothiocyanate moiety, based on rhodol, were designed and synthesized in order to obtain materials with excellent optical properties for the detection of environmentally and biologically important Hg2+ and hypochlorous acid (HClO) ions. The crystal structure of 1 revealed two moieties, a rhodamine‐like portion with a spirolactone and a fluorescein‐like portion without a spirolactone. In the absence of analyte, 1 produced an optical output with a maximum absorption and emission at 475 and 570 nm, respectively, which was attributed to the fluorescein‐like moiety without a spirolactone. In contrast, the rhodamine‐like moiety containing a spirolactone was activated by the addition of H+ or Hg2+ ions, and 1 yielded new absorption and emission peaks at 530 and 612 nm, respectively. Further functionalization with a phenyl isothiocyanate group afforded 2, a fluorescent probe for HClO. High selectivity and sensitivity towards the hypochlorite ion were anticipated, owing to the stoichiometric and irreversible formation of a thiosemicarbazide group, which led to dramatic fluorescence responses. With good functionality at physiological pH, probe 2 was successfully used to image HClO in HeLa cells.
登录
查看更多内容
影响因子：
15
作者：
Dickinson BC;Huynh C;Chang CJ
通讯作者：
Chang CJ
影响因子：
4.9
作者：
Goswami, Shyamaprosad;Manna, Abhishek;Fun, Hoong-Kun
通讯作者：
Fun, Hoong-Kun
影响因子：
7.4
作者：
Goswami, Shyamaprosad;Das, Avijit Kumar;Abdel-Aziz, Hatem A.
通讯作者：
Abdel-Aziz, Hatem A.
影响因子：
4.6
作者：
Burdette, SC;Lippard, SJ
通讯作者：
Lippard, SJ
具有荧光素和罗丹明光谱行为的分子变色龙
影响因子：
4.6
作者：
Li, Ling;Wang, Chunyan;Wong, Keith Man-Chung
通讯作者：
Wong, Keith Man-Chung