Association of quantitative CT lung density measurements and lung function decline in World Trade Center workers.
Association of quantitative CT lung density measurements and lung function decline in World Trade Center workers.
复制标题
定量CT肺密度测量与世界贸易中心工人肺功能下降的相关性
DOI：
10.1111/crj.13313
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
de la Hoz RE
中科院分区：
文献类型：
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作者：
Liu X;Reeves AP;Antoniak K;San José Estépar R;Doucette JT;Jeon Y;Weber J;Xu D;Celedón JC;de la Hoz RE
Occupational exposures at the WTC site after 11 September 2001 have been associated with presumably inflammatory chronic lower airway diseases. In this study, we describe the trajectories of expiratory air flow decline, identify subgroups with adverse progression, and investigate the association of those trajectories with quantitative computed tomography (QCT) imaging measurement of increased and decreased lung density. We examined the trajectories of expiratory air flow decline in a group of 1,321 former WTC workers and volunteers with at least three periodic spirometries, and using QCT‐measured low (LAV%, −950 HU) and high (HAV%, from −600 to −250 HU) attenuation volume percent. We calculated the individual regression line slopes for first‐second forced expiratory volume (FEV1slope), identified subjects with rapidly declining (“accelerated decliners”) and increasing (“improved”), and compared them to subjects with “intermediate” (0 to −66.5 mL/year) FEV1slope. We then used multinomial logistic regression to model those three trajectories, and the two lung attenuation metrics. The mean longitudinal FEV1 slopes for the entire study population, and its intermediate, decliner, and improved subgroups were, respectively, −40.4, −34.3, −106.5, and 37.6 mL/year. In unadjusted and adjusted analyses, LAV% and HAV% were both associated with “accelerated decliner” status (ORadj, 95% CI 2.37, 1.41–3.97, and 1.77, 1.08–2.89, respectively), compared to the intermediate decline. Longitudinal FEV1 decline in this cohort, known to be associated with QCT proximal airway inflammation metric, is also associated with QCT indicators of increased and decreased lung density. The improved FEV1 trajectory did not seem to be associated with lung density metrics.
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影响因子：
4.8
作者：
Washko, George R.;Lynch, David A.;Matsuoka, Shin;Ross, James C.;Umeoka, Shigeaki;Diaz, Alejandro;Sciurba, Frank C.;Hunninghake, Gary M.;Estepar, Raul San Jose;Silverman, Edwin K.;Rosas, Ivan O.;Hatabu, Hiroto
通讯作者：
Hatabu, Hiroto
影响因子：
4.3
作者：
de la Hoz RE;Shapiro M;Nolan A;Celedón JC;Szeinuk J;Lucchini RG
通讯作者：
Lucchini RG
影响因子：
24.3
作者：
Miller, MR;Hankinson, J;Wanger, J
通讯作者：
Wanger, J
影响因子：
5.8
作者：
Ash, Samuel Y.;Harmouche, Rola;Washko, George R.
通讯作者：
Washko, George R.
DOI：
10.1164/ajrccm.152.3.7663792
发表时间：
1995-09-01
影响因子：
24.7
作者：
通讯作者：
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