C-Peptide replacement therapy in type 1 diabetes: are we in the trough of disillusionment?

C-Peptide replacement therapy in type 1 diabetes: are we in the trough of disillusionment?
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C 肽替代疗法治疗 1 型糖尿病:我们正处于幻灭的低谷吗?

DOI:
10.1039/c7mb00199a
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发表时间:
2017
影响因子:
--
通讯作者:
Spence,DM
Spence,DM
中科院分区:
生物3区
文献类型:
--
作者:
Pinger,CW;Entwistle,KE;Bell,TM;Liu,Y;Spence,DM

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1型糖尿病与失明、肾衰竭和神经损伤等并发症有关。取代C肽,一种通常与胰岛素共同分泌的激素,已被证明可以减少糖尿病相关的并发症。有趣的是,经过近30年的积极研究结果,C肽仍然没有与胰岛素一起用于糖尿病患者。下面的综述讨论了C肽作为辅助替代疗法的潜力,以及为什么它目前没有被用作治疗药物。
Type 1 diabetes is associated with such complications as blindness, kidney failure, and nerve damage. Replacing C-peptide, a hormone normally co-secreted with insulin, has been shown to reduce diabetes-related complications. Interestingly, after nearly 30 years of positive research results, C-peptide is still not being co-administered with insulin to diabetic patients. The following review discusses the potential of C-peptide as an auxilliary replacement therapy and why it's not currently being used as a therapeutic.
比较人血清白蛋白在不同糖化阶段形成的修饰位点。
DOI: 10.1016/j.cca.2010.10.018
发表时间: 2011-01-30
期刊: Clinica chimica acta; international journal of clinical chemistry
影响因子: --
作者:
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通讯作者: Hage DS
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期刊: Clinica chimica acta; international journal of clinical chemistry
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发表时间: 2001-06-01
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糖尿病、肥胖和新陈代谢
DOI: 10.1111/dom.13635
发表时间: 2019
期刊: Diabetes
影响因子: 7.7
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DOI: 10.1039/b917600d
发表时间: 2010-01-01
期刊: ANALYST
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