Review: Glycation of human serum albumin.
Review: Glycation of human serum albumin.
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DOI：
10.1016/j.cca.2013.07.013
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发表时间：
2013-10-21
期刊：
影响因子：
--
通讯作者：
Hage DS
中科院分区：
文献类型：
--
作者：
Anguizola J;Matsuda R;Barnaby OS;Hoy KS;Wa C;DeBolt E;Koke M;Hage DS
糖基化涉及将还原糖和/或其反应性降解产物非酶加到蛋白质上的胺基上。糖尿病患者血糖浓度升高会促进这一过程，并与包括人血清白蛋白（HSA）在内的多种蛋白质一起发生。本文综述了在糖化人血蛋白的研究和分析中所做的工作。讨论了HSA的一般结构和性质，以及在糖基化过程中可能导致该蛋白修饰的反应。研究了糖化人血蛋白作为糖尿病患者血糖控制的中短期标志物的使用，并总结了用于测量糖化人血蛋白的方法。本文综述了糖基化人血蛋白的结构研究，包括体内和体外糖基化人血蛋白，以及关于人血蛋白糖基化的速率和热力学的数据。此外，本综述考虑了各种研究糖基化对HSA与药物、脂肪酸和其他溶质结合的影响，以及这些影响的潜在临床意义。
Glycation involves the non-enzymatic addition of reducing sugars and/or their reactive degradation products to amine groups on proteins. This process is promoted by the presence of elevated blood glucose concentrations in diabetes and occurs with various proteins that include human serum albumin (HSA). This review examines work that has been conducted in the study and analysis of glycated HSA. The general structure and properties of HSA are discussed, along with the reactions that can lead to modification of this protein during glycation. The use of glycated HSA as a short-to-intermediate term marker for glycemic control in diabetes is examined, and approaches that have been utilized for measuring glycated HSA are summarized. Structural studies of glycated HSA are reviewed, as acquired for both in vivo and in vitro glycated HSA, along with data that have been obtained on the rate and thermodynamics of HSA glycation. In addition, this review considers various studies that have investigated the effects of glycation on the binding of HSA with drugs, fatty acids and other solutes and the potential clinical significance of these effects.
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比较人血清白蛋白在不同糖化阶段形成的修饰位点。
DOI：
10.1016/j.cca.2010.10.018
发表时间：
2011-01-30
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
Barnaby OS;Cerny RL;Clarke W;Hage DS
通讯作者：
Hage DS
影响因子：
5.8
作者：
BOHNEY, JP;FELDHOFF, RC
通讯作者：
FELDHOFF, RC
影响因子：
4.8
作者：
Ahmed, N;Dobler, D;Thornalley, PJ
通讯作者：
Thornalley, PJ
DOI：
10.1001/archpedi.1976.02120110075010
发表时间：
1976-01-01
影响因子：
--
作者：
CHASE, HP;GLASGOW, AM
通讯作者：
GLASGOW, AM
影响因子：
3.9
作者：
Baraka-Vidot, Jennifer;Guerin-Dubourg, Alexis;Rondeau, Philippe
通讯作者：
Rondeau, Philippe