Influence of Housing Temperature and Genetic Diversity on Allogeneic T Cell-Induced Tissue Damage in Mice.
Influence of Housing Temperature and Genetic Diversity on Allogeneic T Cell-Induced Tissue Damage in Mice.
复制标题
环境温度和遗传多样性对小鼠同种异体T细胞诱导的组织损伤的影响。
DOI：
10.3390/pathophysiology30040039
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发表时间：
2023-11-20
期刊：
影响因子：
--
通讯作者：
Grisham MB
中科院分区：
文献类型：
--
作者：
Enriquez J;McDaniel Mims B;Stroever S;Dos Santos AP;Jones-Hall Y;Furr KL;Grisham MB
本研究的目的是确定房屋温度和遗传多样性如何影响同种异体T细胞诱导的组织损伤的发生和严重程度的小鼠进行降低强度条件反射（RIC）。我们发现，将同种异体CD 4 + T细胞从近交系供体过继转移到标准饲养温度（ST; 22-24 °C）下饲养的亚致死剂量辐照近交系受体（I→I）中，在不损伤任何其他组织的情况下诱导广泛的BM和脾脏损伤。尽管在热中性温度（TNT; 30-32 °C）下饲养的RIC处理的小鼠中植入T细胞也发生了类似的BM和脾损伤，但与ST对应物相比，它们的存活率显著增加。相比之下，过继转移同种异体T细胞到RIC处理的远系CD 1受体未能诱导疾病的任何组织在ST或TNT。组织损伤的缺乏不是由于供体T细胞运输到BM或脾脏的缺陷，而是与这些组织中存在大量B细胞和髓样细胞相关，已知这些组织含有免疫抑制调节B细胞和髓源性抑制细胞。这些数据首次证明，饲养温度影响RIC处理的I→I小鼠的存活率，并且RIC处理的远系小鼠对同种异体T细胞诱导的BM和脾脏损伤具有抗性。
The objective of this study was to determine how housing temperature and genetic diversity affect the onset and severity of allogeneic T cell-induced tissue damage in mice subjected to reduced intensity conditioning (RIC). We found that adoptive transfer of allogeneic CD4+ T cells from inbred donors into sub-lethally irradiated inbred recipients (I→I) housed at standard housing temperatures (ST; 22–24 °C) induced extensive BM and spleen damage in the absence of injury to any other tissue. Although engraftment of T cells in RIC-treated mice housed at their thermo-neutral temperature (TNT; 30–32 °C) also developed similar BM and spleen damage, their survival was markedly and significantly increased when compared to their ST counterparts. In contrast, the adoptive transfer of allogeneic T cells into RIC-treated outbred CD1 recipients failed to induce disease in any tissue at ST or TNT. The lack of tissue damage was not due to defects in donor T cell trafficking to BM or spleen but was associated with the presence of large numbers of B cells and myeloid cells within these tissues that are known to contain immunosuppressive regulatory B cells and myeloid-derived suppressor cells. These data demonstrate, for the first time, that housing temperature affects the survival of RIC-treated I→I mice and that RIC-conditioned outbred mice are resistant to allogeneic T cell-induced BM and spleen damage.
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影响因子：
7.3
作者：
通讯作者：
--
DOI：
10.1038/s41571-020-0356-4
发表时间：
2020-08
期刊：
Nature reviews. Clinical oncology
影响因子：
--
作者：
Blazar BR;Hill GR;Murphy WJ
通讯作者：
Murphy WJ
影响因子：
8
作者：
Lee, Kang Mi;Fu, Qiang;Huai, Guoli;Deng, Kevin;Lei, Ji;Kojima, Lisa;Agarwal, Divyansh;van Galen, Peter;Kimura, Shoko;Tanimine, Naoki;Washburn, Laura;Yeh, Heidi;Naji, Ali;Rickert, Charles G.;LeGuern, Christian;Markmann, James F.
通讯作者：
Markmann, James F.
影响因子：
6.4
作者：
Graham JB;Thomas S;Swarts J;McMillan AA;Ferris MT;Suthar MS;Treuting PM;Ireton R;Gale M Jr;Lund JM
通讯作者：
Lund JM
影响因子：
2.6
作者：
Chen, Jichun;Desierto, Marie J.;Feng, Xingmin;Biancotto, Angelique;Young, Neal S.
通讯作者：
Young, Neal S.