The emerging role of regulatory cell-based therapy in autoimmune disease.
The emerging role of regulatory cell-based therapy in autoimmune disease.
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DOI：
10.3389/fimmu.2022.1075813
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
自身免疫性疾病是由对自身抗原的不必要的免疫反应引起的，每年影响数百万人，并对个人和社区造成巨大的社会和经济负担。在自身免疫性疾病（包括类风湿性关节炎、系统性红斑狼疮、1型糖尿病和多发性硬化症）的过程中，针对有害物质的免疫应答和对自身抗原的耐受性之间的平衡的紊乱导致针对自身组织的免疫应答。近年来，已经鉴定了各种调节性免疫细胞。这些细胞的质量、数量和功能的破坏与自身免疫性疾病的发展有关。因此，靶向或工程化这些细胞是一种有前途的治疗不同的自身免疫性疾病。调节性T细胞、调节性B细胞、调节性树突状细胞、髓样抑制细胞和先天性淋巴样细胞的一些亚群作为这类细胞中的重要参与者而出现。在这里，我们回顾了每种抑制性细胞类型在免疫系统中的作用，在稳态和自身免疫的发展。此外，我们还讨论了这些细胞类型中的每一种在自身免疫性疾病中的当前和未来的治疗潜力。
Autoimmune disease, caused by unwanted immune responses to self-antigens, affects millions of people each year and poses a great social and economic burden to individuals and communities. In the course of autoimmune disorders, including rheumatoid arthritis, systemic lupus erythematosus, type 1 diabetes mellitus, and multiple sclerosis, disturbances in the balance between the immune response against harmful agents and tolerance towards self-antigens lead to an immune response against self-tissues. In recent years, various regulatory immune cells have been identified. Disruptions in the quality, quantity, and function of these cells have been implicated in autoimmune disease development. Therefore, targeting or engineering these cells is a promising therapeutic for different autoimmune diseases. Regulatory T cells, regulatory B cells, regulatory dendritic cells, myeloid suppressor cells, and some subsets of innate lymphoid cells are arising as important players among this class of cells. Here, we review the roles of each suppressive cell type in the immune system during homeostasis and in the development of autoimmunity. Moreover, we discuss the current and future therapeutic potential of each one of these cell types for autoimmune diseases.
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影响因子：
17.1
作者：
Chen, Pauline P.;Cepika, Alma-Martina;Agarwal-Hashmi, Rajni;Saini, Gopin;Uyeda, Molly J.;Louis, David M.;Cieniewicz, Brandon;Narula, Mansi;Hernandez, Laura C. Amaya;Harre, Nicholas;Xu, Liwen;Thomas, Benjamin Craig;Ji, Xuhuai;Shiraz, Parveen;Tate, Keri M.;Margittai, Dana;Bhatia, Neehar;Meyer, Everett;Bertaina, Alice;Davis, Mark M.;Bacchetta, Rosa;Roncarolo, Maria Grazia
通讯作者：
Roncarolo, Maria Grazia
DOI：
10.1016/s1470-2045(13)70512-6
发表时间：
2014-01
期刊：
The Lancet. Oncology
影响因子：
--
作者：
Choi SW;Braun T;Chang L;Ferrara JL;Pawarode A;Magenau JM;Hou G;Beumer JH;Levine JE;Goldstein S;Couriel DR;Stockerl-Goldstein K;Krijanovski OI;Kitko C;Yanik GA;Lehmann MH;Tawara I;Sun Y;Paczesny S;Mapara MY;Dinarello CA;DiPersio JF;Reddy P
通讯作者：
Reddy P
DOI：
10.4049/jimmunol.0803052
发表时间：
2009-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Blair PA;Chavez-Rueda KA;Evans JG;Shlomchik MJ;Eddaoudi A;Isenberg DA;Ehrenstein MR;Mauri C
通讯作者：
Mauri C
影响因子：
2.4
作者：
Kim J;Lee HJ;Yoo IS;Kang SW;Lee JH
通讯作者：
Lee JH
影响因子：
8.6
作者：
Boks, Martine A.;Kager-Groenland, Judith R.;ten Brinke, Anja
通讯作者：
ten Brinke, Anja