Pathways: Strategies for susceptibility genes in SLE.
Pathways: Strategies for susceptibility genes in SLE.
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DOI：
10.1016/j.autrev.2010.02.003
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发表时间：
2010-05
影响因子：
13.6
通讯作者：
Kimberly, Robert P.
中科院分区：
文献类型：
--
作者：
Kelley, James M.;Edberg, Jeffrey C.;Kimberly, Robert P.
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder marked by an inappropriate immune response to nuclear antigens. Recent whole genome association and more focused studies have revealed numerous genes implicated in this disease process, including ITGAM, Fc gamma receptors, complement components, C-reactive protein, and others. One common feature of these molecules is their involvement in the immune opsonins pathway and phagocytic clearing of nuclear antigens and apoptotic debris which provide excessive exposure of lupus-related antigens to immune cells. Analysis of gene-gene interactions in the opsonin pathway and its relationship to SLE may provide a systems-based approach to identify additional candidate genes associated with disease able to account for a larger part of lupus susceptibility.
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