Autosomal short tandem repeat genetic variation of the Basques in Spain
Autosomal short tandem repeat genetic variation of the Basques in Spain
复制标题
西班牙巴斯克人的常染色体短串联重复遗传变异
DOI：
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发表时间：
2011
影响因子：
1.9
通讯作者：
Michael H. Crawford
中科院分区：
文献类型：
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作者：
Kristin L. Young;Guangyun Sun;Ranjan Deka;Michael H. Crawford
目的 使用居住在阿拉瓦省、比斯开省、吉普斯夸省和纳瓦拉省 27 个山村的个体的常染色体短串联重复序列 (STR) 数据，通过将巴斯克常染色体 STR 变异与欧洲邻近群体以及北非和高加索地区的拟议祖先群体进行比较，研究西班牙现代巴斯克群体起源的群体遗传结构和假设。方法测定西班牙巴斯克地区4个省（n = 377）的9个常染色体STR基因座（D3S1358、D5S818、D7S820、D8S1179、D13S317、D18S51、D21S11、FGA和vWA）的等位基因频率和几个群体遗传参数。使用分子方差的逐位点分析来测量巴斯克群体内的杂合性。使用 Shriver 的 DSW 距离矩阵的多维标度 (MDS) 图检查了巴斯克人和其他人群之间的关系。结果巴斯克省的杂合性水平处于欧洲分布的低端（0.805-0.812）。遗传距离的 MDS 图显示巴斯克人在常染色体 STR 变异方面与高加索人和北非人群不同。结论 常染色体 STR 分析不支持巴斯克人和高加索或北非人群之间最近共同祖先的假设。
Aim To examine population genetic structure and hypotheses of the origin of the modern Basque population in Spain using autosomal short tandem repeat (STR) data from individuals living in 27 mountain villages in the provinces of Alava, Vizcaya, Guipuzcoa, and Navarre, by comparing Basque autosomal STR variation with that of neighboring populations in Europe, as well as proposed ancestral populations in North Africa and the Caucasus. Methods Allele frequencies for 9 autosomal STR loci (D3S1358, D5S818, D7S820, D8S1179, D13S317, D18S51, D21S11, FGA, and vWA) and several population genetic parameters were determined for the 4 provinces in the Basque region of Spain (n = 377). Heterozygosity within the Basque population was measured using a locus-by-locus analysis of molecular variance. Relationships between the Basques and other populations were examined using a multidimensional scaling (MDS) plot of Shriver’s DSW distance matrix. Results Heterozygosity levels in the Basque provinces were on the low end of the European distribution (0.805-0.812). The MDS plot of genetic distances revealed that the Basques differed from both the Caucasian and North African populations with respect to autosomal STR variation. Conclusions Autosomal STR analysis does not support the hypotheses of a recent common ancestor between the Basques and populations either from the Caucasus or North Africa.
影响因子：
3.3
作者：
L. Excoffier;P. Smouse;J. Quattro
通讯作者：
L. Excoffier;P. Smouse;J. Quattro
影响因子：
1.9
作者：
GUO, SW;THOMPSON, EA
通讯作者：
THOMPSON, EA