Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation.
Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation.
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DOI：
10.1186/s13054-018-2217-4
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发表时间：
2018-10-29
期刊：
影响因子：
--
通讯作者：
Donnino MW
中科院分区：
文献类型：
--
作者：
Moskowitz A;Andersen LW;Huang DT;Berg KM;Grossestreuer AV;Marik PE;Sherwin RL;Hou PC;Becker LB;Cocchi MN;Doshi P;Gong J;Sen A;Donnino MW
硫胺素、抗坏血酸和氢化可的松的组合最近已成为脓毒症和脓毒性休克患者抗生素、感染源控制和支持性护理的潜在替代疗法。在本手稿中，我们提供了一个全面的审查病理生理基础和支持研究的每一个元素的硫胺素，抗坏血酸，氢化可的松药物组合在脓毒症。此外，我们描述了这些疗法之间的协同作用的潜在领域，并讨论了迄今为止的两项研究的优点/缺点，这两项研究评估了严重感染患者的药物组合。最后，我们描述了目前的临床实践的现状，因为它涉及到硫胺素，抗坏血酸和氢化可的松的组合，并提出了一个随机，安慰剂对照，多中心抗坏血酸，皮质类固醇和硫胺素在脓毒症（SAH）试验和其他计划/正在进行的随机临床试验的概述。
The combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and septic shock. In the present manuscript, we provide a comprehensive review of the pathophysiologic basis and supporting research for each element of the thiamine, ascorbic acid, and hydrocortisone drug combination in sepsis. In addition, we describe potential areas of synergy between these therapies and discuss the strengths/weaknesses of the two studies to date which have evaluated the drug combination in patients with severe infection. Finally, we describe the current state of current clinical practice as it relates to the thiamine, ascorbic acid, and hydrocortisone combination and present an overview of the randomized, placebo-controlled, multi-center Ascorbic acid, Corticosteroids, and Thiamine in Sepsis (ACTS) trial and other planned/ongoing randomized clinical trials.
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DOI：
10.1186/s13054-015-1131-2
发表时间：
2015-11-27
期刊：
Critical care (London, England)
影响因子：
--
作者：
Carr AC;Shaw GM;Fowler AA;Natarajan R
通讯作者：
Natarajan R
影响因子：
15.8
作者：
Ioannidis, JPA
通讯作者：
Ioannidis, JPA
影响因子：
3.3
作者：
Armour, J;Tyml, K;Wilson, JX
通讯作者：
Wilson, JX
影响因子：
1.5
作者：
Corcoran, T. B.;O'Neill, M. A.;Ho, K. M.
通讯作者：
Ho, K. M.
影响因子：
120.7
作者：
Annane, D;Sébille, V;Bellissant, E
通讯作者：
Bellissant, E