A Systematic Review and Meta-Analysis of Transcranial Direct Current Stimulation to Remediate Age-Related Cognitive Decline in Healthy Older Adults.
A Systematic Review and Meta-Analysis of Transcranial Direct Current Stimulation to Remediate Age-Related Cognitive Decline in Healthy Older Adults.
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DOI：
10.2147/ndt.s259499
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发表时间：
2021
影响因子：
3.2
通讯作者：
Woods AJ
中科院分区：
文献类型：
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作者：
Indahlastari A;Hardcastle C;Albizu A;Alvarez-Alvarado S;Boutzoukas EM;Evangelista ND;Hausman HK;Kraft J;Langer K;Woods AJ
经颅直流电刺激（tDCS）已被提出作为一种可能的方法，用于治疗老年人群中与年龄相关的认知能力下降。虽然tDCS已显示出改善健康老年人认知功能的潜力，但各种认知领域的刺激结果好坏参半。在4个数据库中进行了系统检索：PubMed、EMBASE、Web of Science和PsychInfo。然后根据入选/排除标准筛选检索结果的合格性，仅包括应用tDCS改善65岁及以上健康老年人认知的研究。对符合条件的研究进行了审查，并提取了人口统计学特征、tDCS剂量参数、研究程序和认知结局。在代表性认知领域中，将活性药物组与假手术组相比的报告效应量转换为Hedges g。荟萃分析共纳入了13项涉及健康老年人（n=532，平均年龄=71.2 ± 5.3岁）的研究。大多数纳入的研究（94%）针对前额皮质，刺激强度为1-2 mA，使用各种电极放置，阳极靠近额叶区域。在所有研究中，我们发现Hedges的g值范围为-0.31至1.85，这是主动刺激与假刺激相比的组效应量。虽然观察到的结果各不相同，但总体研究结果表明，tDCS对矫正认知老化具有良好的效果，因此值得进一步探索。tDCS剂量反应的个体间变异性的未来表征和在更大队列中的应用是必要的，以进一步验证tDCS对健康老年人认知的益处。
Transcranial direct current stimulation (tDCS) has been proposed as a possible method for remediating age-associated cognitive decline in the older adult population. While tDCS has shown potential for improving cognitive functions in healthy older adults, stimulation outcomes on various cognitive domains have been mixed. A systematic search was performed in four databases: PubMed, EMBASE, Web of Science, and PsychInfo. Search results were then screened for eligibility based on inclusion/exclusion criteria to only include studies where tDCS was applied to improve cognition in healthy older adults 65 years and above. Eligible studies were reviewed and demographic characteristics, tDCS dose parameters, study procedures, and cognitive outcomes were extracted. Reported effect sizes for active compared to sham group in representative cognitive domain were converted to Hedges’ g. A total of thirteen studies involving healthy older adults (n=532, mean age=71.2+5.3 years) were included in the meta-analysis. The majority of included studies (94%) targeted the prefrontal cortex with stimulation intensity 1–2 mA using various electrode placements with anodes near the frontal region. Across all studies, we found Hedges’ g values ranged from −0.31 to 1.85 as reported group effect sizes of active stimulation compared to sham. While observed outcomes varied, overall findings indicated promising effects of tDCS to remediate cognitive aging and thus deserves further exploration. Future characterization of inter-individual variability in tDCS dose response and applications in larger cohorts are warranted to further validate benefits of tDCS for cognition in healthy older adults.
DOI：
10.1080/09658211.2013.861916
发表时间：
2014
期刊：
Memory (Hove, England)
影响因子：
--
作者：
Payne BR;Gross AL;Parisi JM;Sisco SM;Stine-Morrow EA;Marsiske M;Rebok GW
通讯作者：
Rebok GW