Acrolein: A Potential Mediator of Oxidative Damage in Diabetic Retinopathy.
Acrolein: A Potential Mediator of Oxidative Damage in Diabetic Retinopathy.
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DOI：
10.3390/biom10111579
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发表时间：
2020-11-20
期刊：
影响因子：
5.5
通讯作者：
Narayanan SP
中科院分区：
文献类型：
--
作者：
Alfarhan M;Jafari E;Narayanan SP
糖尿病视网膜病变(DR)是劳动年龄成年人视力丧失的主要原因。大量证据表明，氧化应激在Dr.Acrolein的发病机制中起着关键作用，它是多胺氧化和脂质过氧化的产物，已被证明参与了多种人类疾病的发病机制。丙烯醛的有害作用通过多种机制介导，包括DNA损伤、炎症、ROS形成、蛋白质内化、膜破裂、内质网应激和线粒体功能障碍。最近的研究报道了丙烯醛在DR的发病机制中的作用，这些研究表明，在糖尿病情况下，丙烯醛对视网膜神经血管单位有不利影响。本文综述了丙烯醛的来源，丙烯醛在糖尿病视网膜氧化损伤中的作用，以及丙烯醛在DR发病机制中的作用机制，并讨论了可能的治疗干预措施，如使用多胺氧化酶抑制剂、具有抗氧化性能的药物和丙烯醛清除剂来降低丙烯醛的毒性。
Diabetic retinopathy (DR) is the leading cause of vision loss among working-age adults. Extensive evidences have documented that oxidative stress mediates a critical role in the pathogenesis of DR. Acrolein, a product of polyamines oxidation and lipid peroxidation, has been demonstrated to be involved in the pathogenesis of various human diseases. Acrolein’s harmful effects are mediated through multiple mechanisms, including DNA damage, inflammation, ROS formation, protein adduction, membrane disruption, endoplasmic reticulum stress, and mitochondrial dysfunction. Recent investigations have reported the involvement of acrolein in the pathogenesis of DR. These studies have shown a detrimental effect of acrolein on the retinal neurovascular unit under diabetic conditions. The current review summarizes the existing literature on the sources of acrolein, the impact of acrolein in the generation of oxidative damage in the diabetic retina, and the mechanisms of acrolein action in the pathogenesis of DR. The possible therapeutic interventions such as the use of polyamine oxidase inhibitors, agents with antioxidant properties, and acrolein scavengers to reduce acrolein toxicity are also discussed.
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影响因子：
5.2
作者：
Conklin, Daniel J.;Prough, Russell A.;Juvan, Peter;Rezen, Tadeja;Rozman, Damjana;Haberzettl, Petra;Srivastava, Sanjay;Bhatnagar, Aruni
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4.2
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2
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通讯作者：
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