Pulmonary vascular enlargement and lesion extent on computed tomography are correlated with COVID-19 disease severity.
Pulmonary vascular enlargement and lesion extent on computed tomography are correlated with COVID-19 disease severity.
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DOI：
10.1007/s11604-020-01085-2
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发表时间：
2021-05
影响因子：
2.1
通讯作者：
Ogura T
中科院分区：
文献类型：
--
作者：
Aoki R;Iwasawa T;Hagiwara E;Komatsu S;Utsunomiya D;Ogura T
为了评估肺血管增大、用软件量化的计算机断层扫描(CT)结果和冠状病毒病(新冠肺炎)严重程度之间的关系。分析了87例(男性50例，女性37例；中位年龄63岁)经实时荧光聚合酶链式反应确诊的新冠肺炎患者的超高分辨率CT图像。CT测量最大亚段血管内径。用软件测量磨玻璃样阴影、网状影和实变的CT肺总体积(CTLV总体积)和病变范围(病变体积与CTLV总体积之比)。肺血管最大内径与病变范围采用Spearman相关分析。对CT结果进行Logistic回归分析以预测疾病严重程度。我们还在16名患者的随访扫描中评估了这些指标的变化。23例重症患者均有血管增大( 为4 mm)。校正年龄和合并合并症后，肺血管增大(优势比3.0 5，p = 0.018)和CT病变范围(优势比1.0 7，p = 0.002)是疾病严重程度的独立预测因素。随访时CT显示血管内径和病变体积减小(分别为p = 0.001和p = 0.002)，但CTLV总量无明显变化。亚节段血管增大是预测急性新冠肺炎疾病严重程度的一个值得注意的发现。网上版载有补充材料，可在10.1007/s11604-020-01085-2查阅。
To assess the relationships among pulmonary vascular enlargement, computed tomography (CT) findings quantified with software, and coronavirus disease (COVID-19) severity. Ultra-high-resolution (UHR) CT images of 87 patients (50 males, 37 females; median age, 63 years) with COVID-19 confirmed using real-time polymerase chain reaction were analyzed. The maximum subsegmental vascular diameter was measured on CT. Total CT lung volume (CTLV total) and lesion extent (ratio of lesion volume to CTLV total) of ground-glass opacities, reticulation, and consolidation were measured using software. Maximum pulmonary vascular diameter and lesion extent were analyzed using Spearman’s correlation analysis. Logistic regression analysis was performed on CT results to predict disease severity. We also assessed changes in these measures on follow-up scans in 16 patients. All 23 patients with severe and critical illness had vascular enlargement (> 4 mm). Pulmonary vascular enlargement (odds ratio 3.05, p = 0.018) and CT lesion extent (odds ratio 1.07, p = 0.002) were independent predictors of disease severity after adjustment for age and comorbidities. On follow-up CT, vascular diameter and CT lesion volume decreased (p = 0.001, p = 0.002; respectively), but CTLV total did not change significantly. Subsegmental vascular enlargement is a notable finding to predict acute COVID-19 disease severity. The online version contains supplementary material available at 10.1007/s11604-020-01085-2.
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影响因子：
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DOI：
10.1164/rccm.202004-1412oc
发表时间：
2020-09-01
影响因子：
24.7
作者：
Patel, Brijesh, V;Arachchillage, Deepa J.;Desai, Sujal R.
通讯作者：
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