Triterpenoid saponins with hepatoprotective effects from the fresh leaves of Metapanax delavayi
Triterpenoid saponins with hepatoprotective effects from the fresh leaves of Metapanax delavayi
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紫花鲜叶中具有保肝作用的三萜皂苷
DOI：
10.1080/14786419.2018.1512987
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发表时间：
2018-11
影响因子：
2.2
通讯作者：
Zhang Ying-Jun
中科院分区：
文献类型：
--
作者：
Wei Xin;Gao Da-Fang;Abe Yuko;Tanaka Yoshihisa;Zhu Hong-Tao;Wang Dong;Yang Chong-Ren;Zhang Ying-Jun
摘要：在中国云南省的五加科植物中，鲜叶已被当地人用作一种常见的野生蔬菜，用于制作沙拉和汤，以及凉茶。详细的化学研究鉴定了一种新的三萜皂苷，3-O-α- l-阿拉伯吡喃-28- o -β- d -葡萄糖吡喃-(1→6)- o -β- d -葡萄糖吡喃-3β-羟基齐墩-12-烯-28,29-二酸(1)，以及11种已知化合物，包括6种三萜皂苷（2-7），2种咖啡酰奎宁酸衍生物（8-9）和3种黄酮类苷（10-12）。通过光谱分析和酸水解确定了它们的结构。其中化合物3 ~ 5、8 ~ 12为首次从该植物中分离得到。此外，已知皂苷3- o -β- d - xylopyranoyl -3 -β- hydroxyolean-12-ene-28,29-dioic acid(3)和yiyeliangwanoside IV(5)在浓度为1.0 μ g/mL时对酒精摄入损伤的HepG2细胞有保护作用。结果表明，龙葵是一种理想的膳食蔬菜和具有潜在保肝活性的凉茶。
Abstract The fresh leaves of Metapanax delavayi (Araliaceae) have been used as a common wild vegetable for salad and soup, and also herbal tea by the local people living in its growing areas of Yunnan province, China. Detailed chemical investigation led to the identification of a new triterpenoid saponin, 3-O-α-L-arabinopyranosyl-28-O-β-D-glucopyranosyl-(1→6)-O-β-D-glucopyranosyl-3β-hydroxyolean-12-ene-28,29-dioic acid (1) from the fresh leaves, together with 11 known compounds, including six triterpenoid saponins (2–7), two caffeoylquinic acid derivatives (8–9), and three flavonoid glycosides (10–12). Their structures were determined on the basis of spectroscopic analysis and acidic hydrolysis. Compounds 3–5 and 8–12 were isolated from M. delavayi for the first time. Moreover, the known saponins 3-O-β-D-xylopyranosyl-3β-hydroxyolean-12-ene-28,29-dioic acid (3) and yiyeliangwanoside IV (5) exhibited protective effects on HepG2 cells damaged by the alcohol intakes, at a concentration of 1.0 µg/mL. The results indicated M. delavayi is an ideal dietary vegetable and herbal tea with potential hepatoprotective activity.
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DOI：
--
发表时间：
1991
期刊：
Yao xue xue bao = Acta pharmaceutica Sinica
影响因子：
--
作者：
S. S. Yu-S.;Z. Xiao
通讯作者：
S. S. Yu-S.;Z. Xiao
影响因子：
2.1
作者：
Shichun Yu;Zhuo-yin Xiao;P. Cai;Tian-Yi Jiang;J. Snyder
通讯作者：
Shichun Yu;Zhuo-yin Xiao;P. Cai;Tian-Yi Jiang;J. Snyder
影响因子：
3.8
作者：
VEIT, M;GEIGER, H;MARKHAM, KR
通讯作者：
MARKHAM, KR
影响因子：
1.8
作者：
Osna N;Kharbanda K;Schrum L;Dolganiuc A
通讯作者：
Dolganiuc A
影响因子：
--
作者：
Beier JI;Arteel GE;McClain CJ
通讯作者：
McClain CJ